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Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases.
5-Azacytidine. A new anticancer drug with effectiveness in acute myelogenous leukemia.
Clinical results in solid tumors are not encouraging, but 5-azacytidine shows consistent antitumor activity in patients with acute myelogenous leukemia resistant to previous treatment.
Cis-diamminedichloroplatinum (II). A new anticancer drug.
- M. Rozencweig, D. V. Von Hoff, M. Slavik, F. Muggia
- Medicine, ChemistryAnnals of internal medicine
- 1 June 1977
Gastrointestinal, renal, audiologic, and relatively minor hematologic toxicities may be encountered, but promising methods have been developed to increase the therapeutic index of DDP.
Quantitative prediction of drug toxicity in humans from toxicology in small and large animals.
If the starting dose in Phase 1 clinical trials had been selected by calculating one-third of the toxic dose low (in mg/sq m) in the most sensitive large animal species, 5 of the 30 drugs would have produced significant toxicity in the first patient.
Interactions of lectins with membrane glycoproteins. Effects of concanavalin A on 5'-nucleotidase.
Pyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusion
- C. Fabian, R. Molina, M. Slavik, S. Dahlberg, S. Giri, R. Stephens
- MedicineInvestigational New Drugs
- 1 February 1990
Considering the high incidence of PPE and response in previously untreated colon cancer patients who receive protracted continuous 5-FU, prophylactic pyridoxine in conjunction with this treatment modality might be useful.
Phase I clinical trial of spirogermanium.
The principal clinical toxic effects observed in this phase I trial were neurologic, manifested as lethargy, dizziness, and ataxia, while a grand mal seizure was produced after an accidental overdose.
High sensitivity ELISA determination of taxol in various human biological fluids.
Phase I trial and pharmacokinetic study of intravenous and oral alpha-difluoromethylornithine.
Eflornithine-HCl (alpha-difluoromethylornithine or DFMO), an irreversible inhibitor of ornithine decarboxylase, blocks polyamine synthesis and has demonstrated antitumor activity in cell culture and…
Chemotherapy of cancer
This guide covers every anticancer drug commonly used in Europe and the United States and includes new advances in combined modality therapy and immunotherapy, as well as new anticancer drugs now being tested in laboratories around the world.