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A measure of population subdivision based on microsatellite allele frequencies.
TLDR
It was found that, under the generalized stepwise mutation model, R( ST) provides relatively unbiased estimates of migration rates and times of population divergence while F(ST) tends to show too much population similarity, particularly when migration rates are low or divergence times are long. Expand
ISOLATION BY DISTANCE IN EQUILIBRIUM AND NON‐EQUILIBRIUM POPULATIONS
  • M. Slatkin
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 February 1993
TLDR
Analytical theory shows that there is a simple relationship between M̂ and geographic distance in both equilibrium and non‐equilibrium populations and that this relationship is approximately independent of mutation rate when the mutation rate is small. Expand
Finding the missing heritability of complex diseases
Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture.Expand
Estimation of levels of gene flow from DNA sequence data.
TLDR
It is found that in general when there is no recombination, the cladistic method performed better than FST while the reverse was true for rates of recombination similar to those found in eukaryotic nuclear genes, although FST performed better for all recombination rates for very low levels of migration. Expand
A Draft Sequence of the Neandertal Genome
TLDR
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other. Expand
Gene flow and the geographic structure of natural populations.
TLDR
Of particular interest are those species for which direct methods indicate little current gene flow but indirect methods indicate much higher levels of gene flow in the recent past, and whose species probably have undergone large-scale demographic changes relatively frequently. Expand
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.
TLDR
An expectation-maximization (EM) algorithm leading to maximum-likelihood estimates of molecular haplotype frequencies under the assumption of Hardy-Weinberg proportions is implemented and appears to be useful for the analysis of nuclear DNA sequences or highly variable loci. Expand
Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations.
TLDR
In an exponentially growing population in which the product of the current population size and the growth rate is substantially larger than one, the analytical and simulation results show that most coalescent events occur relatively early and in a restricted range of times. Expand
A COMPARISON OF THREE INDIRECT METHODS FOR ESTIMATING AVERAGE LEVELS OF GENE FLOW
  • M. Slatkin, N. Barton
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 November 1989
TLDR
The conclusion is that, although FST and rare‐alleles methods are expected to be equally effective in analyzing ideal data, practical problems in estimating the frequencies of rare alleles in electrophoretic studies suggest that FST is likely to be more useful under realistic conditions. Expand
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