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A measure of population subdivision based on microsatellite allele frequencies.
A new measure of the extent of population subdivision as inferred from allele frequencies at microsatellite loci is proposed and tested with computer simulations. This measure, called R(ST), isExpand
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Finding the missing heritability of complex diseases
Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture.Expand
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  • M. Slatkin
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 February 1993
It is shown that for allele frequency data a useful measure of the extent of gene flow between a pair of populations is M∘=(1/FST‐1)/4 , which is the estimated level of gene flow in an island modelExpand
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Estimation of levels of gene flow from DNA sequence data.
We compare the utility of two methods for estimating the average levels of gene flow from DNA sequence data. One method is based on estimating FST from frequencies at polymorphic sites, treating eachExpand
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A Draft Sequence of the Neandertal Genome
Kissing Cousins Neandertals, our closest relatives, ranged across Europe and Southwest Asia before their extinction approximately 30,000 years ago. Green et al. (p. 710) report a draft sequence ofExpand
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Gene flow and the geographic structure of natural populations.
There is abundant geographic variation in both morphology and gene frequency in most species. The extent of geographic variation results from a balance of forces tending to produce local geneticExpand
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Gene Flow in Natural Populations
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Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.
Molecular techniques allow the survey of a large number of linked polymorphic loci in random samples from diploid populations. However, the gametic phase of haplotypes is usually unknown when diploidExpand
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Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations.
We consider the distribution of pairwise sequence differences of mitochondrial DNA or of other nonrecombining portions of the genome in a population that has been of constant size and in a populationExpand
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Testing for ancient admixture between closely related populations.
One enduring question in evolutionary biology is the extent of archaic admixture in the genomes of present-day populations. In this paper, we present a test for ancient admixture that exploits theExpand
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