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Glycoprotein-D-adjuvant vaccine to prevent genital herpes.
BACKGROUND An effective prophylactic vaccine would help control the spread of genital herpes. METHODS We conducted two double-blind, randomized trials of a herpes simplex virus type 2 (HSV-2)Expand
A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group.
A recombinant vaccine based on fusion of the circumsporozoite protein and HBsAg plus a potent adjuvant can protect against experimental challenge with P. falciparum malaria. Expand
Drug discovery: A jump-start for electroceuticals
Kristoffer Famm and colleagues unveil a multidisciplinary initiative to develop medicines that use electrical impulses to modulate the body's neural circuits.
Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine.
Twenty malaria-naive volunteers received a recombinant Plasmodium falciparum malaria vaccine (RTS,S) containing 19 NANP repeats and the carboxy terminus of the circumsporozoite (CS) antigen coexpressed in yeast with hepatitis B surface antigen and MPL enhanced CS antibody levels. Expand
Pertussis-specific cell-mediated immunity in infants after vaccination with a tricomponent acellular pertussis vaccine
The data show that the vaccine induces T-cell responses specific for the vaccine components, detoxified pertussis toxin, filamentous hemagglutinin, and pertactin, that increase progressively over the course of the vaccination schedule, and cell-mediated immune responses are stable over the postprimary to prebooster period. Expand
Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs.
Guinea pigs Immunized with gD2/AS04 were significantly better protected against recurrent disease than were guinea pigs immunized with a gD 2/Al vaccine, which suggests that inclusion of 3-dMPL improved protection against latent infection. Expand
Pulmonary lesions in primary respiratory syncytial virus infection, reinfection, and vaccine-enhanced disease in the cotton rat (Sigmodon hispidus).
Animal primed with formalin-inactivated virus and challenged after 49 days had pulmonary viral titers 1/10 to 1/100 of that seen in naive animals, but developed markedly accentuated lesions of the same type as in animals undergoing primary or secondary infection, which seem to be specific markers for the vaccine enhancement. Expand
Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine.
Further optimization in vaccine composition and/or immunization schedule will be required to induce longer-lasting protective immunity in malaria sporozoite vaccine candidate RTS,S. Expand
Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system.
Results indicate that the new formulation of recombinant hepatitis B surface antigen combined with a novel adjuvant system, SBAS4--a combination of aluminium salt and monophosphoryl lipid A--is safe, well-tolerated and immunogenic and may promote more rapid protection against hepatitis B infection. Expand
Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine.
RTS, S/SBAS2 is a potent inducer of Th1-type cellular and humoral immunity and its results highlight possible immune mechanisms of protection and have important implications for vaccine design in general. Expand