• Publications
  • Influence
Presenting ENCODE
TLDR
Nine years after launch, its main efforts culminate in the publication of 30 coordinated papers, 6 of which are in this issue of Nature, and more than 80% of the human genome’s components have now been assigned at least one biochemical function.
Allele Frequency Database
  • M. Skipper
  • Biology
    Nature Reviews Genetics
  • 1 September 2003
TLDR
The database provides access to allele frequency data from a wide range of human population samples and links these data to the molecular genetics and human genome databases, and can be searched using a unique identifier (UID) that allows identification of a record across many data tables.
Into Africa
Getting to the guts of enteroendocrine differentiation
TLDR
Two studies disclose that Notch signalling controls which cells differentiate as enteroendocrine cells—a finding with implications for therapeutic strategy.
Epigenomics: Epigenetic variation across the generations
  • M. Skipper
  • Biology
    Nature Reviews Genetics
  • 12 October 2011
TLDR
The first genome-wide insights into heritable epigenetic variation are provided, pointing out that CG methylation of transposable-element-rich regions appears to be more stable than that of protein-coding genes and siRNAs have a role in stabilizing methylation.
Would Mendel have been a blogger?
  • M. Skipper
  • Education
    Nature Reviews Genetics
  • 1 September 2006
Chromosome biology: Global architecture
TLDR
The authors’ previous findings that heat-shock proteins can also reveal hidden genetic variation, Lindquist and colleagues prompt us to reexamine protein folding mechanisms, for they could be unexpectedly important in translating genotypes into phenotypes.
Autism Genome Project
  • M. Skipper
  • Biology
    Nature Reviews Genetics
  • 1 September 2004
TLDR
Two studies reveal that large deletions and duplications are more common than was previously thought, prompting a re-evaluation of the way the authors view human genetic variation.
Presenting the Epigenome Roadmap
TLDR
Research in this issue is accompanied by an online collection — the Epigenome Roadmap — which unites research from across Nature Publishing Group journals, as well as news stories and multimedia.
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