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ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins
TLDR
We present a web-based version of ProSA, ProSA-web, that encompasses the basic functionality of stand-alone ProSA and extends it with new features that facilitate interpretation of the results obtained. Expand
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Recognition of errors in three‐dimensional structures of proteins
  • M. Sippl
  • Chemistry, Medicine
  • Proteins
  • 1 December 1993
A major problem in the determination of the three‐dimensional structure of proteins concerns the quality of the structural models obtained from the interpretation of experimental data. NewExpand
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  • 120
Calculation of conformational ensembles from potentials of mean force. An approach to the knowledge-based prediction of local structures in globular proteins.
  • M. Sippl
  • Chemistry, Medicine
  • Journal of molecular biology
  • 20 June 1990
We present a prototype of a new approach to the folding problem of polypeptide chains. This approach is based on the analysis of known protein structures. It derives the energy potentials for theExpand
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  • 55
Boltzmann's principle, knowledge-based mean fields and protein folding. An approach to the computational determination of protein structures
  • M. Sippl
  • Chemistry, Computer Science
  • J. Comput. Aided Mol. Des.
  • 1 August 1993
TLDR
Boltzmann's principle enables the extraction of information on protein-solvent systems in the form of potentials of mean force. Expand
  • 368
  • 22
ProSup: a refined tool for protein structure alignment.
We investigated and optimized a method for structure comparison which is based on rigid body superimposition. The method maximizes the number of structurally equivalent residues while keeping theExpand
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  • 22
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Knowledge-based potentials for proteins.
  • M. Sippl
  • Computer Science, Medicine
  • Current opinion in structural biology
  • 1 April 1995
TLDR
Knowledge based potentials and energy functions are extracted from a number of databases of known protein structures. Expand
  • 580
  • 20
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High-performance signal peptide prediction based on sequence alignment techniques
TLDR
We demonstrate that the popular BLASTP alignment tool can be tuned for signal peptide prediction reaching the same high level of prediction success. Expand
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Identification of native protein folds amongst a large number of incorrect models. The calculation of low energy conformations from potentials of mean force.
We present an approach that is able to detect native folds amongst a large number of non-native conformations. The method is based on the compilation of potentials of mean force of the interactionsExpand
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Structure-based evaluation of sequence comparison and fold recognition alignment accuracy.
TLDR
We describe a benchmark protocol to estimate sequence-to-sequence and sequence- to-structure alignment accuracy. Expand
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  • 9
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