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- Publications
- Influence
Cancer preventive properties of ginger: a brief review.
Ginger, the rhizome of Zingiber officinalis, one of the most widely used species of the ginger family, is a common condiment for various foods and beverages. Ginger has a long history of medicinal… Expand
Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice
SummaryBackground Due to lack of validated screening methods and hence poor prognosis, treatment of lung cancer has not still improved up to the expectations. Therefore, risk of lung cancer needs to… Expand
Tea polyphenols enhance cisplatin chemosensitivity in cervical cancer cells via induction of apoptosis.
AIM
Constitutive activation of nuclear factor-kappaB (NF-κB) and Akt has been implicated in chemoresistance as well as inhibition of apoptosis to cisplatin (CDDP), therefore, we examined whether (-)… Expand
Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells.
- M. Singh, R. Singh, K. Bhui, Shilpa Tyagi, Z. Mahmood, Y. Shukla
- Biology, Medicine
- Oncology research
- 1 June 2011
Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. However, studies elucidating the role and the mechanism(s) of action of tea… Expand
Bromelain inhibits nuclear factor kappa‐B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G2/M arrest to apoptosis
- K. Bhui, Shilpa Tyagi, +4 authors Y. Shukla
- Biology, Medicine
- Molecular carcinogenesis
- 1 March 2012
Bromelain, obtained from pineapple, is already in use clinically as adjunct in chemotherapy. Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe its… Expand
Hydrological inferences from watershed analysis for water resource management using remote sensing and GIS techniques
Abstract The present study highlights the importance of Digital Elevation Model (DEM) and satellite images for assessment of drainage and extraction of their relative parameters for the Orr watershed… Expand
Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis
- N. Nigam, Jasmine George, +4 authors Y. Shukla
- Biology, Medicine
- Cancer Chemotherapy and Pharmacology
- 1 March 2010
PurposeTo unravel the molecular mechanisms underlying the chemopreventive potential of [6]-gingerol, a pungent ingredient of ginger rhizome (Zingiber officinale Roscoe, Zingiberaceae), against… Expand
Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice.
AIM
To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice.
METHODS
Oral treatment of lupeol (1… Expand
In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]-gingerol.
- Y. Shukla, S. Prasad, Chitra Tripathi, M. Singh, Jasmine George, N. Kalra
- Biology, Medicine
- Molecular nutrition & food research
- 1 December 2007
Ginger (Zingiber officinale, Zingiberaceae) has been widely used as a dietary spice, and as a traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones, including… Expand
Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways.
Prostate cancer (PCA), the most frequently diagnosed malignancy in men, represents an excellent candidate disease for chemoprevention studies because of its particularly long latency period, high… Expand