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The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease
TLDR
The M-ANNHEIM multiple risk factor classification system is simple, objective, accurate, and relatively noninvasive, and it incorporates etiology, different stages of the disease, and various degrees of clinical severity. Expand
Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases.
TLDR
Age of voluntary alcohol drinking onset does not appear to be a strong predictor for prospective alcohol intake and relapse-like drinking behavior under the present experimental conditions, however, male Wistar rats that initiated alcohol consumption during adolescence seem to be more susceptible to acute stressor-specific effects in terms of alcohol consumption. Expand
A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake.
TLDR
Wistar, HAD, P, and AA rats differentially respond to alcohol deprivation and stress, showing that the genetic background of these different rat lines profoundly affects relapse-like drinking and stress-induced drinking. Expand
Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease
TLDR
It is suggested that in IBD psychological variables, particularly depressive coping, are more predictive than medical variables for disease-related concerns and other variables of health-related quality of life. Expand
The etiology of liver damage imparts cytokines transforming growth factor β1 or interleukin‐13 as driving forces in fibrogenesis
TLDR
Immunohistochemistry results suggest that IL‐13–mediated liver fibrogenesis may take place in the absence of phospho–signal transducer and activator of transcription protein 6 signaling, andDepending on the cause of liver damage, a predominance of TGF‐β orIL‐13 signaling is found. Expand
TGF-beta/Smad signaling in the injured liver.
TLDR
This review summarizes the knowledge about TGF-beta signal transduction in HSCs with special impact on Smad pathways and introduces hepatocyte plasticity and epithelial-to-mesenchymal transition in the liver, which is well established in tumorigenesis, as a potential feature of fibrogenesis and possible action points of T GF-beta in these contexts. Expand
Novel generation of hormone receptor specificity by amino terminal processing of peptide YY.
TLDR
It is shown that PYY-II is as potent as PYY for the inhibition of pancreatic secretion, which must occur through Y2 receptors, and Amino terminal processing of PYY represents a novel type of regulation of peptide hormone specificity. Expand
Responsiveness of intestinal epithelial cell lines to lipopolysaccharide is correlated with Toll-like receptor 4 but not Toll-like receptor 2 or CD14 expression
TLDR
Receptor expression and signaling pathways involved in activation of human primary IEC and carcinoma-derived cell lines by lipopolysaccharide (LPS) are analyzed and Responsiveness of IEC lines to LPS is positively correlated with TLR 4 expression. Expand
Hepatitis B core antigen is a potent inductor of interleukin‐18 in peripheral blood mononuclear cells of healthy controls and patients with hepatitis B infection
TLDR
Results indicate that HBcAg induces IL‐18 secretion by induction of Caspase‐1, and differential regulation in HBeAg‐negative and positive patients suggests an important role of IL‐ 18 in CHB infection. Expand
Esophageal motility disorders in critically ill patients: a 24-hour manometric study
TLDR
Irrespective of the underlying disease, propulsive motility of the esophageal body is significantly reduced during any kind of sedation in critically ill patients and analysis according to the underlying diseases showed marked inhibition of motility parameters within any disease group in comparison with controls. Expand
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