M. Singer

Publications774
h-index88
Citations51,775
Highly Influential Citations2,075
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
TLDR
The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016
TLDR
Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
View on Wolters Kluwer
Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
TLDR
To evaluate the validity of clinical criteria to identify patients with suspected infection who are at risk of sepsis, a new model derived using multivariable logistic regression in a split sample was derived.
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
TLDR
Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
View on Springer
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of…
Objective:To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients. Participants:A multidisciplinary, multispecialty task…
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Association between mitochondrial dysfunction and severity and outcome of septic shock
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Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology.
TLDR
It is of great importance that guidelines and recommendations are presented in formats that are easily interpreted and their implementation programmes must also be well conducted.
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Hydrocortisone therapy for patients with septic shock.
TLDR
Hydrocortisone did not improve survival or reversal of shock in patients with septic shock, either overall or in patients who did not have a response to corticotropin, although hydroc Cortisone hastened reversal ofshock in patients in whom shock was reversed.
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Trial of early, goal-directed resuscitation for septic shock.
TLDR
In patients with septic shock who were identified early and received intravenous antibiotics and adequate fluid resuscitation, hemodynamic management according to a strict EGDT protocol did not lead to an improvement in outcome.
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Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
TLDR
A consensus process using results from a systematic review, surveys, and cohort studies found that adult patients with septic shock can be identified using the clinical criteria of hypotension requiring vasopressor therapy to maintain mean BP 65 mm Hg or greater and having a serum lactate level greater than 2 mmol/L after adequate fluid resuscitation.
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