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Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration.
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Rapid IgE desensitization is antigen specific and impairs early and late mast cell responses targeting FcεRI internalization
TLDR
It is demonstrated that rapid IgE desensitization is antigen specific and inhibits early and late mast cell activation responses and internalization of the antigen/IgE/FcεRI complexes.
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A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.
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Hypersensitivity to antineoplastic agents: mechanisms and treatment with rapid desensitization
TLDR
The current literature on molecular mechanisms of RDD is reviewed with an emphasis in the recent contributions to this field as well as the indications, methods and outcomes of R DD for taxanes, platins, and monoclonal antibodies.
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Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.
TLDR
It is concluded that in activated T cells, the SAP protein binds to and regulates signal transduction events initiated through the engagement of SLAM, 2B4, CD84, and Ly-9, which suggests that combinations of dysfunctional signaling pathways initiated by these 4 cell surface receptors may cause the complex phenotypes of XLP.
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T-cell Intracellular Antigen-1 (TIA-1)-induced Translational Silencing Promotes the Decay of Selected mRNAs*
TLDR
The results suggest that TIA-1-induced polysome disassembly is required for enhanced mRNA decay and that Tia- 1-induced translational silencing promotes the decay of selected mRNAs.
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Signaling through CD5 involves acidic sphingomyelinase, protein kinase C-zeta, mitogen-activated protein kinase kinase, and c-Jun NH2-terminal kinase.
TLDR
Early biochemical events triggered by CD5 stimulation, which include the phosphatidylcholine-specific phospholipase C (PC-PLC)-dependent activation of acidic sphingomyelinase (A-SMase) in normal and lymphoblastoid T and B cells, are described.
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Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein kinase II.
TLDR
It is demonstrated that casein kinase II associates with and phosphorylates the C-terminal region of CD5, a conserved domain known to be relevant for the generation of second lipid messengers, and thereby enables at least one component of its signaling function.
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Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.
TLDR
This report shows that CD150 colocalizes with the T-cell receptor (TCR) following CD3 triggering in human peripheral blood T cells and is rapidly and reversibly tyrosine phosphorylated on TCR cross-linking.
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SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.
TLDR
It is demonstrated that SAP is an adaptor that bridges SLAM and Ly9 with Src-like protein tyrosine kinases (PTKs), and has the ability to activate FynT.
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