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GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.
TLDR
It is suggested that pp36-38 may be a bridging protein, coupling different signalling molecules to cytoplasmic PTKs regulated by the TCR, and low levels of PLC-gamma 1 are detected in GRB2 immunoprecipitates in support of this notion. Expand
CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.
TLDR
Evidence is provided that CD45 can modulate the binding of the Lck to an 11 amino acid tyrosine phosphorylated peptide containing the carboxy‐terminus of Lck (lckP), and data suggest thatCD45 specifically modulates the conformation of Lk in a manner consistent with the intramolecular model of regulation of Src‐like kinases. Expand
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
TLDR
The ability of gp120 to inhibit the binding of class II MHC to CD4 could be important in disrupting normal T-cell physiology, acting both to inhibit immune responses and to prevent differentiation of CD4+CD8+ thymocytes into CD4 +CD8− T lymphocytes. Expand
Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells.
TLDR
The primary structure of murine CD3 eta is reported as deduced from protein microsequencing and cDNA cloning, consistent with the notion that CD3 Eta may be an important component of a T-cell receptor isoform(s) during thymic development. Expand
CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development.
TLDR
RNase protection analysis with RNA from a variety of fetal, neonatal, and adult cell types indicates that expression of both gene products is T-lineage-restricted and posttranscriptional and/or transcriptional regulatory mechanisms control CD3 zeta and CD3 eta expression during T-cell development. Expand
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
GRB2, a 25-kDa protein comprising a single SH2 domain flanked by two SH3 domains, has been implicated in linking receptor protein tyrosine kinases (PTKs) to the Ras pathway by interacting with theExpand