M. Siegler

Publications325
h-index38
Citations4,961
Highly Influential Citations20
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Discovery of the aggregation pheromone of the brown marmorated stink bug (Halyomorpha halys) through the creation of stereoisomeric libraries of 1-bisabolen-3-ols.
We describe a novel and straightforward route to all stereoisomers of 1,10-bisaboladien-3-ol and 10,11-epoxy-1-bisabolen-3-ol via the rhodium-catalyzed asymmetric addition of trimethylaluminum to… Expand
IPr* an easily accessible highly hindered N-heterocyclic carbene.
Herein, we wish to describe the efficient three-step synthesis of a novel highly hindered, but flexible, N-heterocyclic carbene and its coordination chemistry to Ag(i) and Rh(i).
Dramatically Accelerated Selective Oxygen-Atom Transfer by a Nonheme Iron(IV)-Oxo Complex: Tuning of the First and Second Coordination Spheres
The new ligand N3PyamideSR and its FeII complex [FeII(N3PyamideSR)](BF4)2 (1) are described. Reaction of 1 with PhIO at −40 °C gives metastable [FeIV(O)(N3PyamideSR)]2+ (2), containing a sulfide… Expand
Ketones as directing groups in photocatalytic sp3 C–H fluorination† †Electronic supplementary information (ESI) available. CCDC 1556373, 1556374 and 1556555. For ESI and crystallographic data in CIF…
Visible light-sensitization allows conformationally rigid ketones to act as “directing groups” for aliphatic fluorination using Selectfluor, catalytic benzil, and LEDs.
Redox Chemistry
Three strikes aN2d you’re out! The spontaneous azide decomposition on mononuclear ruthenium complexes bearing a redox-active aminophenol-derived tridentate NNO ligand selectively generates a rare… Expand
Direct, catalytic monofluorination of sp³ C-H bonds: a radical-based mechanism with ionic selectivity.
Recently, our group unveiled a system in which an unusual interplay between copper(I) and Selectfluor effects mild, catalytic sp(3) C-H fluorination. Herein, we report a detailed reaction mechanism… Expand
Evidence for a Symmetrical Fluoronium Ion in Solution
Fluorine Learns to Share Though halides typically coordinate to just one carbon center, their transient coordination to a second carbon (forming a positively charged bridge) explains the spatial… Expand
Coordination chemistry and reactivity of a cupric hydroperoxide species featuring a proximal H-bonding substituent.
At -90 °C in acetone, a stable hydroperoxo complex [(BA)Cu(II)OOH](+) (2) (BA, a tetradentate N(4) ligand possessing a pendant -N(H)CH(2)C(6)H(5) group) is generated by reacting… Expand
A N3S(thioether)-ligated Cu(II)-superoxo with enhanced reactivity.
Previous efforts to synthesize a cupric superoxide complex possessing a thioether donor have resulted in the formation of an end-on trans-peroxo-dicopper(II) species,… Expand
Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes
HighlightsVamorolone (VBP15) is a steroidal drug that has shown dissociative properties.The X‐ray crystal structure of vamorolone is presented.In a Phase 1 clinical trial in adult volunteers,… Expand
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