Interrogating a high-density SNP map for signatures of natural selection.
An analysis of single nucleotide polymorphisms with allele frequencies that were determined in three populations provides a first generation natural selection map of the human genome and provides compelling evidence that selection has shaped extant patterns of human genomic variation.
SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans
It is shown that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor.
Estimating African American admixture proportions by use of population-specific alleles.
Significant nonrandom association between two markers located 22 cM apart (FY-null and AT3) is detected, most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations, emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental population.
Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and zebu cattle (Bos taurus and Bos indicus).
The introgression of zebu-specific alleles in African cattle afforded a high resolution perspective on the hybrid nature of African cattle populations and also suggested that certain West African populations of valuable disease-tolerant taurine cattle are under threat of genetic absorption by migrating zebe herds.
Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data
The results indicate that several key HIF-regulatory and targeted genes are responsible for adaptation to high altitude in Andeans and Tibetans, and several different chromosomal regions are implicated in the putative response to selection.
Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes
The results suggest that the migration of modern humans out of Africa into new environments was accompanied by genetic adaptations to emergent selective forces, and a region containing four contiguous genes on Chromosome 7 showed striking evidence of a recent selective sweep in European-Americans.
A novel measure of genetic distance for highly polymorphic tandem repeat loci.
- M. Shriver, L. Jin, E. Boerwinkle, R. Deka, R. Ferrell, R. Chakraborty
- BiologyMolecular biology and evolution
- 1 September 1995
A measure of genetic distance, DSW, which is appropriate for the analysis of highly polymorphic DNA loci, and the applicability of DSW to evolutionary analysis is demonstrated by reconstructing the relationships among eight human populations using 14 microsatellite and STR loci.
Genetic evidence for the convergent evolution of light skin in Europeans and East Asians.
A case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians is supported by the testing for the presence of positive directional selection in 6 pigmentation genes using an empirical F(ST) approach and a role for MATP in determining normal skin pigmentation variation using admixture mapping methods.
Control of confounding of genetic associations in stratified populations.
These methods can deal with both confounding and selection bias in genetic-association studies, making family-based designs unnecessary, and are demonstrated by using data from three admixed populations in which there is extreme confounding of trait-genotype associations.
Skin pigmentation, biogeographical ancestry and admixture mapping
This work indicates that it is possible to estimate the individual ancestry of a person based on DNA analysis with a reasonable number of well-defined genetic markers, as well as applying two methods of admixture mapping to test for the effects of three candidate genes.