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Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles.
TLDR
The present study suggested the possibility that gene expression profiling may be useful in predicting response to radiotherapy to establish an individualized tailored therapy for rectal cancer. Expand
Deficiency of phospholipase C-γ1 impairs renal development and hematopoiesis
TLDR
Data suggest that PLC-gamma1 plays an essential role in the renal development and hematopoiesis in vivo and to a lesser extent compared with control wild-type ES cells. Expand
Schedule-dependent antitumor activity of the combination with erlotinib and docetaxel in human non-small cell lung cancer cells with EGFR mutation, KRAS mutation or both wild-type EGFR and KRAS.
TLDR
It is demonstrated that docetaxel followed by erlotinib therapy was a potentially optimum regimen against NSCLC regardless of the mutation status of EGFR and KRAS. Expand
Site-specific activation of dopamine and serotonin transmission by aniracetam in the mesocorticolimbic pathway of rats
TLDR
Findings indicate that SHRSP have a dopaminergic hypofunction throughout the brain and that aniracetam elicits a site-specific activation in mesocorticolimbic dopaminaergic and serotonergic pathways inSHRSP, possibly via nicotinic acetylcholine receptors in the ventral tegmental area and raphe nuclei. Expand
Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis
TLDR
The results suggest that maspin has a potential role for tumour metastasis in gastric cancer. Expand
Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome
TLDR
A population of breast cancer cells that overexpress the cell cycle-related transcription factor, E2F-5 is identified for the first time, and was associated with an ER(−/PgR(−)/HER2(−) status, a basal phenotype, and a worse clinical outcome. Expand
Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP
TLDR
Results indicate that aniracetam enhances DA and 5-HT release by mainly mediating the action of N-anisoyl-GABA that targets not only somatodendritic nA Ch and NMDA receptors but also presynaptic nACh receptors. Expand
Immunohistochemical Ki67 labeling index has similar proliferation predictive power to various gene signatures in breast cancer
TLDR
The data indicate that I HC Ki67 shows similar predictive power for proliferation in ER‐positive cancers as genomic markers, and further study of IHC Ki67 is needed to define prognostic factors and predictive factors for chemotherapy using central laboratory assessment. Expand
Deficiency of phospholipase C-gamma1 impairs renal development and hematopoiesis.
TLDR
Data suggest that PLC-gamma1 plays an essential role in the renal development and hematopoiesis in vivo and to a lesser extent compared with control wild-type ES cells. Expand
Activation of the reticulothalamic cholinergic pathway by the major metabolites of aniracetam.
TLDR
Data prove that aniracetam can facilitate central cholinergic neurotransmission via both metabolites and based on its pharmacokinetic profile, N-anisoyl-GABA may contribute to the clinical effects of anir acetam, mainly by acting on the reticulothalamic Cholinergic pathway. Expand
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