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Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles.
Preoperative radiotherapy has been widely used to improve local control of disease and to improve survival in the treatment of rectal cancer. However, the response to radiotherapy differs among… Expand
Deficiency of phospholipase C-γ1 impairs renal development and hematopoiesis
Phospholipase C-γ1 (PLC-γ1) is involved in a variety of intracellular signaling via many growth factor receptors and T-cell receptor. To explore the role of PLC-γ1 in vivo, we generated the… Expand
Schedule-dependent antitumor activity of the combination with erlotinib and docetaxel in human non-small cell lung cancer cells with EGFR mutation, KRAS mutation or both wild-type EGFR and KRAS.
- K. Furugaki, T. Iwai, M. Shirane, K. Kondoh, Y. Moriya, K. Mori
- Biology, Medicine
- Oncology reports
- 1 November 2010
Erlotinib is used as a standard treatment for recurrent advanced non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutations in NSCLC have been shown to be a predictive… Expand
Site-specific activation of dopamine and serotonin transmission by aniracetam in the mesocorticolimbic pathway of rats
The effects of aniracetam on extracellular levels of dopamine (DA), serotonin (5-HT) and their metabolites were examined in five brain regions in freely moving stroke-prone spontaneously hypertensive… Expand
Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis
- M. Terashima, C. Maesawa, +13 authors K. Mori
- Medicine, Biology
- British Journal of Cancer
- 15 March 2005
To seek for a candidate gene that would regulate tumour progression and metastasis in gastric cancer, we investigated gene expression profiles by using DNA microarray. Tumour tissue and adjacent… Expand
Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome
The purpose of the present study is to identify genes that contribute to cell proliferation or differentiation of breast cancers independent of signalling through the oestrogen receptor (ER) or human… Expand
Immunohistochemical Ki67 labeling index has similar proliferation predictive power to various gene signatures in breast cancer
The objective of this study was to examine the association between the immunohistochemical Ki67 labeling index (IHC Ki67), Ki67 mRNA expression level, and first‐generation gene signatures in a cohort… Expand
Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP
Aniracetam, a cognition enhancer, has been recently found to preferentially increase extracellular levels of dopamine (DA) and serotonin (5-HT) in the prefrontal cortex (PFC), basolateral amygdala… Expand
The effects of long and short term profound deafness on the responses of inferior colliculus to electrical stimulation of the cochlea.
It is widely assumed that adequate sensory stimulation is important for the proper post-natal development of the central nervous system, particularly during certain critical or sensitive periods in… Expand
Deficiency of phospholipase C-gamma1 impairs renal development and hematopoiesis.
Phospholipase C-gamma1 (PLC-gamma1) is involved in a variety of intracellular signaling via many growth factor receptors and T-cell receptor. To explore the role of PLC-gamma1 in vivo, we generated… Expand