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Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
Species of the genus Streptomyces are of major pharmaceutical interest because they synthesize a variety of bioactive secondary metabolites. We have determined the complete nucleotide sequence of theExpand
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Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
Streptomyces avermitilis is a soil bacterium that carries out not only a complex morphological differentiation but also the production of secondary metabolites, one of which, avermectin, isExpand
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Longispora albida gen. nov., sp. nov., a novel genus of the family Micromonosporaceae.
A novel actinomycete strain was isolated from a soil sample collected in Japan by using gellan gum as a solidifying agent. Spore-chains from the short sporophores were straight and each had more thanExpand
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Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activities.
Blocking human immunodeficiency virus (HIV) entry into target cells is an important goal of HIV and acquired immune deficiency syndrome (AIDS) therapies. We have searched for anti-HIV substances fromExpand
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New inhibitors of melanogenesis, OH-3984 K1 and K2. I. Taxonomy, fermentation, isolation and biological characteristics.
Melanogenesis inhibitors, OH-3984 K1 and K2 were isolated from fermentation broth of Streptomyces sp. OH-3984. OH-3984 K1 and K2 inhibited the melanogenesis of B16 melanoma cells at concentrations ofExpand
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Amphistin, a new melanogenesis inhibitor, produced by an actinomycete.
A new melanogenesis inhibitor, named amphistin, was isolated from the fermentation broth of an actinomycete strain KP-3052. Amphistin was purified from the culture filtrate by the combination ofExpand
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Phthoxazolin, a specific inhibitor of cellulose biosynthesis, produced by a strain of Streptomyces sp.
involved in humanand animal cells, it provides a promising target site for safe and non-selective herbicides of a novel class. Inhibitors of cellulose biosynthesis of microbial origin have not beenExpand
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Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. K93-0711. I. Taxonomy, fermentation, isolation and biological activities.
Selective growth inhibition against IL-6-dependent cells was detected in fermentation extracts of a microbial strain, K93-0711, which was characterized as Streptomyces species. Active metabolite,Expand
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Phthoxazolin A, a specific inhibitor of cellulose biosynthesis from microbial origin. I. Discovery, taxonomy of producing microorganism, fermentation, and biological activity.
A new inhibitor of cellulose biosynthesis named phthoxazolin A was discovered as a metabolite of Streptomyces sp. OM-5714. A newly established screening method, which utilized a cellulose-containingExpand
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Cytosaminomycins, new anticoccidial agents produced by Streptomyces sp. KO-8119. I. Taxonomy, production, isolation and physico-chemical and biological properties.
Streptomyces amakusaensis KO-8119, a soil isolate, was found to produce a series of new anticoccidial compounds. Four active compounds, designated as cytosaminomycins A, B, C and D, were isolatedExpand
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