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Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.
TLDR
The finding of many inhibitors of ADP- ribosyltransferases, especially poly(ADP-ribose) synthetase, supports the view that ADp-ribosylation of proteins may be regulated by a variety of metabolites or structural constituents in the cell.
Molecular Identification of Human Glutamine- and Ammonia-dependent NAD Synthetases
TLDR
The results indicate that the carbon-nitrogen hydrolase domain is the functional domain of NAD synthetase to make use of glutamine as an amide donor in NAD synthesis, and glutamine-dependent NAD Synthetase may be classified as a possible glutamine amidase in the nitrilase family.
Possible participation of glucocorticoid in elevation of 3',5'-cyclic AMP levels through inhibition of cyclic AMP phosphodiesterase.
TLDR
Results suggest that in addition to increasing DNA-dependent RNA polymerase activity in vivo, a large application of glucocorticoid may incur elevation of intracellular cAMP levels.
Glutamic Acid 207 in Rodent T-cell RT6 Antigens Is Essential for Arginine-specific ADP-ribosylation*
A rat T-cell antigen RT6.1 catalyzes NAD glycohydrolysis but not ADP-ribose transfer, even though the antigen has significant amino acid identity with eucaryotic arginine-specific
Amino acid sequence of histone H1 at the ADP-ribose-accepting site and ADP-ribose X histone-H1 adduct as an inhibitor of cyclic-AMP-dependent phosphorylation.
TLDR
Results indicate that ADP-ribosylation of histone H1 occurs at the arginine residue 34, sequenced at the NH2-terminal side of the phosphate-accepting serine residue 38, the site of phosphorylation by cAMP-dependent protein kinase.
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.
TLDR
Arginine-ADP-ribosylated proteins in mouse spleen lymphocytes were identified using this method using the specific hydrolysis of ADp-ribose-arginine bond by GST-ADp- ribosyl arginine hydrolase.
Exocytosis of arginine-specific ADP-ribosyltransferase and p33 induced by A23187 and calcium or serum-opsonized zymosan in chicken polymorphonuclear leukocytes.
TLDR
Evidence is obtained that heterophil transferase and p33 may be involved in neutrophil functions during processes of inflammation, which is interpreted to mean that heterophile-specific ADP-ribosylation of p33 occurred in the extracellular space.
Mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase.
TLDR
It is concluded that mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase, and that Cys-201 confers thiol dependency on Rt 6.1 transferase.
Glycosylphosphatidylinositol-anchored arginine-specific ADP-ribosyltransferase7.1 (Art7.1) on chicken B cells: the possible role of Art7 in B cell receptor signalling and proliferation
TLDR
Light is shed on the Art molecule expressed on B cells and its possible functional role in BCR signalling, as it is demonstrated for the first time that Art7.1 was predominantly expressed on the surface of B cells from the bursa of Fabricius as a GPI-anchored form.
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