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Human genetic variation database, a reference database of genetic variations in the Japanese population
Whole-genome and -exome resequencing using next-generation sequencers is a powerful approach for identifying genomic variations that are associated with diseases. However, systematic strategies forExpand
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Alveolar Bone Marrow as a Cell Source for Regenerative Medicine: Differences Between Alveolar and Iliac Bone Marrow Stromal Cells
We isolated and expanded BMSCs from human alveolar/jaw bone at a high success rate (70%). These cells had potent osteogenic potential in vitro and in vivo, although their chondrogenic and adipogenicExpand
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Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.
OBJECTIVE Although interleukin-17 (IL-17)-producing gamma/delta T cells were reported to play pathogenic roles in collagen-induced arthritis (CIA), their characteristics remain unknown. The aim ofExpand
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Identification of mesenchymal stem cell (MSC)‐transcription factors by microarray and knockdown analyses, and signature molecule‐marked MSC in bone marrow by immunohistochemistry
  • H. Kubo, M. Shimizu, +10 authors Y. Kato
  • Biology, Medicine
  • Genes to cells : devoted to molecular & cellular…
  • 1 March 2009
Although ex vivo expanded mesenchymal stem cells (MSC) have been used in numerous studies, the molecular signature and in vivo distribution status of MSC remain unknown. To address this matter, weExpand
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HLA‐HD: An accurate HLA typing algorithm for next‐generation sequencing data
The accurate typing of human leukocyte antigen (HLA) alleles is critical for a variety of medical applications, such as genomic studies of multifactorial diseases, including immune system andExpand
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Follistatin‐related protein/follistatin‐like 1 evokes an innate immune response via CD14 and toll‐like receptor 4
FRP physically interacts with CD14 by fluorescence‐activated cell sorting (View interaction)
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Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis
Significance Takayasu arteritis (TAK) is a systemic vasculitis with unknown etiology. We identified four unreported susceptibility genes to TAK through genome-wide association studies. WeExpand
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A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production
BackgroundA previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukinExpand
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Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population.
Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although previous studies have revealed that HLA-B*52:01 has an effect on TAK susceptibility, no other geneticExpand
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GM-CSF but Not IL-17 Is Critical for the Development of Severe Interstitial Lung Disease in SKG Mice
Interstitial lung disease (ILD) is a common complication and sometimes a prognostic factor of connective tissue diseases (CTDs) in humans. However, suitable animal model of severe CTD-associated ILDExpand
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