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  • Influence
Oxidants, antioxidants, and the degenerative diseases of aging.
TLDR
It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts. Expand
Oxidative damage and mitochondrial decay in aging.
TLDR
Evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging. Expand
gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention.
TLDR
It is suggested that gamma-tocopherol may contribute significantly to human health in ways not recognized previously, and this possibility should be further evaluated, especially considering that high doses of alpha-tocaperol deplete plasma and tissue gamma-Tocopherol, in contrast with supplementation withGamma-CEHC, which increases both. Expand
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.
TLDR
Dietary AA protects human sperm from endogenous oxidative DNA damage that could affect sperm quality and increase risk of genetic defects, particularly in populations with low AA such as smokers. Expand
Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
TLDR
The results suggest that the age-dependent accumulation of oh8dG residues observed in DNA from liver, kidney, and intestine is principally due to the slow loss of DNA nuclease activity; however, an increase in the rate of oxidative DNA damage cannot be ruled out. Expand
Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
TLDR
Analysis of urine from three species by this method indicates that mice excrete approximately 3.3-fold more 8-hydroxy-2'-deoxyguanosine than humans, a result that supports the proposal that oxidative damage to DNA increases in proportion to species-specific basal metabolic rates. Expand
Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.
TLDR
The induction of CYP1A1 appears to lead to a leak of oxygen radicals and consequent oxidative DNA damage that could lead to mutation and cancer. Expand
DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine.
TLDR
It is found that phenol extraction of DNA contributes a real but minor increase in the level of oxo8dG when compared, under equivalent conditions, with a successful nonphenol method, and a more significant reduction in the baseline level was achieved with a modification of the recently introduced chaotropic NaI method. Expand
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
TLDR
It is concluded that measurements of MDA and isoprostanes in plasma and urine as well as 8-OHdG in urine are potential candidates for general biomarkers of oxidative stress. Expand
Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats
TLDR
Findings provide evidence to support the idea that stress produces oxidants, and that the oxidative damage in stress could contribute to the degenerative diseases of aging, including brain dysfunction. Expand
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