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A new way of enhancing the thermostability of proteases
Surprisingly it is found that a single mutation that decreases thermostability can require two mutations that increase stability to compensate for it, suggesting cooperativity. Expand
YM-215343, a novel antifungal compound from Phoma sp. QN04621.
YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus and showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 microg/ml. Expand
Kalimantacins A, B and C, novel antibiotics from Alcaligenes sp. YL-02632S. I. Taxonomy, fermentation, isolation and biological properties.
The taxonomy of the producing strain, fermentation, isolation and biological activities of kalimantacins are reported and inhibit the growth of Staphylococcus aureus and S. epidermidis including multiple-drug resistant strains. Expand
YM-92447 (spinosulfate A), a neuraminidase inhibitor produced by an unidentified pycnidial fungus.
This research attacked the mode of recognition of E.coli as a “spatially aggregating substance” and found that E. coli can be sexually transmitted through contact chemoreception and “gene recognition” is a natural “corresponding pathway” to HIV. Expand
Massadine, a novel geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa.
The structure of massadine has been deduced from spectral data and it is shown that massidine inhibited GGTase I from Candida albicans with an IC(50) value of 3.9 microM. Expand
YM-30059, a novel quinolone antibiotic produced by Arthrobacter sp.
The strain was identified as a member of the genus Arthrobacter, and named Arth Robacter sp. Expand
Novel aspartyl protease inhibitors, YF-0200R-A and B.
Novel pepstatin A-sensitive Candida albicans aspartyl protease inhibitors are isolated from the fermentation broth of Streptomyces sp. Expand
YM-47522, a novel antifungal antibiotic produced by Bacillus sp. II. Structure and relative stereochemistry.
YM-47522 (1) was isolated from the fermentation broth of Bacillus sp. YL-03709B as an antifungal antibiotic. The structure of 1 was elucidated by spectroscopic analyses. YM-47522 (1) consisted of C13Expand
Corticatic acids D and E, polyacetylenic geranylgeranyltransferase type I inhibitors, from the marine sponge Petrosia corticata.
Two new polyacetylenic acids, corticatic acids D (2) and E (3), have been isolated from the marine sponge Petrosia corticata along with the known corticatic acid A (1) as geranylgeranyltransferaseExpand