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The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling.
Results suggest that Xror2 cooperates with Wnts to regulate convergent extension of the axial mesoderm and neuroectoderm by modulating the planar cell polarity pathway of Wnt.
MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors
The analyses suggest that micro RNA-9 indirectly inhibits Pax6 expression by suppressing Meis2 expression, and together with Elavl1 and Msi1, microRNA-9 targets Nr2e1 mRNA 3′ UTR to enhance the expression.
MicroRNA-9 Modulates Cajal–Retzius Cell Differentiation by Suppressing Foxg1 Expression in Mouse Medial Pallium
- M. Shibata, D. Kurokawa, Hiromi Nakao, Tomomi Ohmura, S. Aizawa
- BiologyJournal of Neuroscience
- 8 October 2008
It is proposed that mouse microRNA-9 (miR-9) targets Foxg1 mRNAs for proper generation of Cajal–Retzius cells in the medial pallium, and Gain- and loss-of-function analyses showed that miR- 9 negatively regulates endogenousFoxg1 protein level.
The PsychENCODE project
The PsychENCODE project aims to produce a public resource of multidimensional genomic data using tissue- and cell type–specific samples from approximately 1,000 phenotypically well-characterized, high-quality healthy and disease-affected human post-mortem brains, as well as functionally characterize disease-associated regulatory elements and variants in model systems.
Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings.
Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis
Xenopus crescent encoding a Frizzled-like domain is expressed in the Spemann organizer and pronephros
Overexpression of S-adenosylmethionine decarboxylase (SAMDC) in early Xenopus embryos induces cell dissociation and inhibits transition from the blastula to gastrula stage.
In SAMDC-overexpressed embryos a SAM-deficient state was induced and this caused cell dissociation and inhibition of transition from the blastula to gastrula stage, suggesting that the SAM- deficient embryos obtained in the present study provide a unique system for studying the cellular control mechanism underlying the Blastula-gastrula transition.
Gene expression pattern analysis of the tight junction protein, Claudin, in the early morphogenesis of Xenopus embryos