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The Proteinase-Activated Receptor 2 Is Involved in Nociception
- W. Hoogerwerf, L. Zou, +6 authors P. Pasricha
- Chemistry, Medicine
- The Journal of Neuroscience
- 15 November 2001
The proteinase-activated receptor 2 is expressed on a subset of primary afferent neurons and may participate in the neurogenic component of inflammation. We hypothesized that this receptor may also… Expand
The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
- J. Winston, M. Shenoy, D. Medley, A. Naniwadekar, P. Pasricha
- 1 February 2007
BACKGROUND & AIMS Robust chemical or mechanical irritation of the colon of neonatal rats leads to chronic visceral hypersensitivity. The clinical and physiologic relevance of such noxious stimulation… Expand
Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis.
- Guang-Yin Xu, J. Winston, M. Shenoy, H. Yin, S. Pendyala, P. Pasricha
- Chemistry, Medicine
- 1 October 2007
BACKGROUND & AIMS The neurobiologic basis of pancreatic hyperalgesia in chronic pancreatitis (CP) is understood poorly and there is a need to identify novel therapeutic targets. Our aim was to study… Expand
Trypsin mediates nociception via the proteinase-activated receptor 2: a potentially novel role in pancreatic pain.
- W. Hoogerwerf, M. Shenoy, J. Winston, Shu-Yuan Xiao, Zhijun He, P. Pasricha
- 1 September 2004
BACKGROUND & AIMS The pathogenesis of pain in pancreatitis remains poorly understood. We hypothesized that trypsin, a key inflammatory mediator in this condition, can also activate nociceptive… Expand
P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterised by abdominal pain and bloating in association with altered bowel movements. Its pathogenesis and the… Expand
Enhanced excitability and suppression of A-type K+ current of pancreas-specific afferent neurons in a rat model of chronic pancreatitis.
- Guang-Yin Xu, J. Winston, M. Shenoy, H. Yin, P. Pasricha
- American journal of physiology. Gastrointestinal…
- 1 September 2006
Chronic pancreatitis (CP) is a relatively common disorder, characterized by glandular insufficiency and chronic, often intractable, pain. The mechanism of pain in CP is poorly understood. We have… Expand
Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis.
BACKGROUND & AIMS The pathogenesis of pain in chronic pancreatitis (CP) is poorly understood and treatment remains difficult. We hypothesized that nerve growth factor (NGF) plays a key role in this… Expand
Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis
BackgroundTransforming growth factor beta (TGFβ) is upregulated in chronic inflammation, where it plays a key role in wound healing and promoting fibrosis. However, little is known about the… Expand
The endogenous hydrogen sulfide producing enzyme cystathionine-β synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome
- Guang-Yin Xu, J. Winston, M. Shenoy, Shufang Zhou, J. Chen, P. Pasricha
- Molecular pain
- 1 January 2009
BackgroundThe pathogenesis of visceral hypersensitivity, a characteristic pathophysiological feature of irritable bowel syndrome (IBS), remains elusive. Recent studies suggest a role for hydrogen… Expand
A rat model of chronic gastric sensorimotor dysfunction resulting from transient neonatal gastric irritation.
- Liansheng Liu, J. Winston, M. Shenoy, Gengqing Song, J. Chen, P. Pasricha
- 1 June 2008
BACKGROUND & AIMS Although several pathophysiologic abnormalities have been noted in functional dyspepsia (FD), their pathogenesis is poorly understood. We hypothesized that chronic gastric… Expand