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miR-26b Promotes Granulosa Cell Apoptosis by Targeting ATM during Follicular Atresia in Porcine Ovary
More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicularExpand
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Involvement of the Up-regulated FoxO1 Expression in Follicular Granulosa Cell Apoptosis Induced by Oxidative Stress*
Background: Granulosa cell (GC) apoptosis is the main cause of follicular atresia, and oxidative stress is involved in this process. Results: GC apoptosis is caused by FoxO1 activity in oxidativeExpand
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Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cells
In mammalian ovaries, follicular atresia occurs periodically and destroys almost all the follicles in the ovary. Follicle-stimulating hormone (FSH) acts as the primary survival factor duringExpand
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3-Nitropropionic Acid Induces Ovarian Oxidative Stress and Impairs Follicle in Mouse
Oxidative stress induces many serious reproductive diseases in female mammals and thus poses a serious threat to reproductive health. However, the relationship between reactive oxygen speciesExpand
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FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy
Oxidative stress has been implicated in triggering granulosa cell (GC) death during follicular atresia. Recent studies suggested that follicle-stimulating hormone (FSH) has a pivotal role inExpand
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FSH prevents porcine granulosa cells from hypoxia‐induced apoptosis via activating mitophagy through the HIF‐1α‐PINK1‐Parkin pathway
  • C. Li, J. Zhou, +5 authors H. Liu
  • Chemistry, Medicine
  • FASEB journal : official publication of the…
  • 20 January 2020
In developing follicles, the granulosa cells (GCs) live in a hypoxic environment due to the devoid of blood supply. Upon hypoxic conditions, several types of mammalian cells have been reported toExpand
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Corticosterone Injection Impairs Follicular Development, Ovulation and Steroidogenesis Capacity in Mice Ovary
Simple Summary Researchers have hitherto established hundreds of animal stress models. However, these models have some limitations due to the complexity in operation and large differences betweenExpand
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Selection of antioxidants against ovarian oxidative stress in mouse model
Oxidative stress (OS) plays an important role in the process of ovarian granulosa cell apoptosis and follicular atresia. The aim of this study was to select antioxidant against OS in ovary tissue.Expand
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Wip1-dependent modulation of macrophage migration and phagocytosis
Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. Controlling macrophage conversion into foam cells remains a major challenge for treatment of atheroscleroticExpand
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Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy
ABSTRACT Oxidative stress-induced granulosa cell (GCs) death represents a common reason for follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from oxidative injury,Expand
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