• Publications
  • Influence
Local force and geometry sensing regulate cell functions
  • V. Vogel, M. Sheetz
  • Biology, Engineering
    Nature Reviews Molecular Cell Biology
  • 1 April 2006
TLDR
Tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms of eukaryotic cells.
The relationship between force and focal complex development
TLDR
It is shown that initial integrin–ECM adhesions become capable of exerting migration force with the recruitment of vinculin, a marker for focal complexes, which are precursors of focal adhesion.
Talin depletion reveals independence of initial cell spreading from integrin activation and traction
TLDR
It is suggested that talin is not required for initial cell spreading, however, talin provides the important mechanical linkage between ligand-bound integrins and the actin cytoskeleton required to catalyse focal adhesion-dependent pathways.
Stretching Single Talin Rod Molecules Activates Vinculin Binding
TLDR
It is shown that mechanical stretching of single cytoplasmic proteins can activate binding of other molecules and molecular mechanotransduction can occur by protein binding after exposure of buried binding sites in the talin-vinculin system.
Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein
TLDR
It is shown that a approximately 20S polypeptide complex (referred to as Activator I) stimulates dynein- mediated vesicle transport and proposes the name dynactin (for dyne in activator), which is required for in vitro vesicles motility.
...
...