• Publications
  • Influence
Stepping up the pressure
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Increased Chondrocyte Apoptosis Is Associated with Progression of Osteoarthritis in Spontaneous Guinea Pig Models of the Disease
Osteoarthritis (OA) is the most common joint disease characterised by degradation of articular cartilage and bone remodelling. For almost a decade chondrocyte apoptosis has been investigated as aExpand
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Cyclic Loading Can Denature Type II Collagen in Articular Cartilage
We sought to explain previously reported associations between osteoarthritis, cartilage collagen denaturation, and repetitive mechanical loading. Eighty specimens of cartilage-on-bone were obtainedExpand
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v-erbA Oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action
The v-erbA oncoprotein of avian erythroblastosis virus is an aberrant version of a thyroid hormone receptor and functions in neoplasia by blocking erythroid differentiation and by modifying theExpand
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The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast
The v-erbA oncogene is a retrovirus-transduced and altered copy of a cellular gene for a thyroid hormone receptor. In animal cells, the v-erbA protein fails to respond to hormone and acts as aExpand
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Malignant transformation by G protein-coupled hormone receptors
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Swelling of articular cartilage depends on the integrity of adjacent cartilage and bone.
Articular cartilage swells when its collagen network is degraded, both in osteoarthritis (OA) and following mechanical trauma. However, most of the experimental evidence actually shows that it isExpand
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