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- Publications
- Influence
How severe must repetitive loading be to kill chondrocytes in articular cartilage?
- K. Clements, Z. C. Bee, G. Crossingham, M. A. Adams, M. Sharif
- Chemistry, Medicine
- Osteoarthritis and cartilage
- 1 July 2001
OBJECTIVE
Little is known about the effects of severe repetitive loading on articular cartilage chondrocytes, even though epidemiological studies associate this type of loading with osteoarthritis.… Expand
Cytokines in osteoarthritis: mediators or markers of joint destruction?
- C. Westacott, M. Sharif
- Medicine
- Seminars in arthritis and rheumatism
- 1 February 1996
OBJECTIVE
The integrity of articular cartilage is maintained by the balance between cytokine-driven anabolic and catabolic processes. Unregulated or excess influences of these molecules are thought… Expand
Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint.
The value of serum cartilage oligomeric matrix protein (COMP) as a marker of disease progression was investigated in 81 hospital out-patients with clinical knee osteoarthritis (OA). Progressing… Expand
Chondrocyte apoptosis: a cause or consequence of osteoarthritis?
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation and changes in the subchondral bone. Over the last two decades, there has been increasing evidence… Expand
A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis--association with disease progression.
- M. Sharif, John R. Kirwan, N. Charni, L. Sandell, C. Whittles, P. Garnero
- Medicine
- Rheumatology
- 1 June 2007
OBJECTIVES
The 5-yr longitudinal study tested the hypothesis that serum and urinary markers of type II collagen metabolism would be associated with radiological progression of disease in patients… Expand
Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee.
OBJECTIVE
To investigate the prognostic value of serum hyaluronic acid (HA) and keratan sulfate (KS) levels in relation to tibiofemoral osteoarthritis (OA) of the knee.
METHODS
Clinical and… Expand
Chondrocyte death by apoptosis is associated with cartilage matrix degradation.
- C. M. Thomas, C. Fuller, C. E. Whittles, M. Sharif
- Chemistry, Medicine
- Osteoarthritis and cartilage
- 1 April 2010
OBJECTIVES
To investigate the frequency of chondrocyte apoptosis in equine articular cartilage (AC) specimens and to examine the relationship between the process of cell death and the degree of… Expand
Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3.
- M. Sharif, A. Whitehouse, P. Sharman, M. Perry, Mike Adams
- Chemistry, Medicine
- Arthritis and rheumatism
- 1 February 2004
OBJECTIVE
Chondrocyte apoptosis has been described in both human and experimentally induced osteoarthritis (OA), but its importance in the etiopathogenesis of OA is uncertain. The aims of this study… Expand
Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage.
- C. J. Fuller, A. Barr, M. Sharif, P. Dieppe
- Medicine
- Osteoarthritis and cartilage
- 2001
OBJECTIVE
To investigate the relationship between biochemical markers in the synovial fluid of osteoarthritic and contralateral equine joints and gross articular cartilage pathology.
DESIGN… Expand
Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee
- M. Sharif, L. Shepstone, C. Elson, P. Dieppe, J. Kirwan
- Medicine
- Annals of the rheumatic diseases
- 1 January 2000
OBJECTIVE Raised serum C reactive protein (CRP) and hyaluronate (HA) concentrations predict the progression of knee osteoarthritis (OA) in the long term but the consistency of these relations with… Expand