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How severe must repetitive loading be to kill chondrocytes in articular cartilage?
OBJECTIVE Little is known about the effects of severe repetitive loading on articular cartilage chondrocytes, even though epidemiological studies associate this type of loading with osteoarthritis.Expand
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Cytokines in osteoarthritis: mediators or markers of joint destruction?
OBJECTIVE The integrity of articular cartilage is maintained by the balance between cytokine-driven anabolic and catabolic processes. Unregulated or excess influences of these molecules are thoughtExpand
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Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint.
The value of serum cartilage oligomeric matrix protein (COMP) as a marker of disease progression was investigated in 81 hospital out-patients with clinical knee osteoarthritis (OA). ProgressingExpand
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Chondrocyte apoptosis: a cause or consequence of osteoarthritis?
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation and changes in the subchondral bone. Over the last two decades, there has been increasing evidenceExpand
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A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis--association with disease progression.
OBJECTIVES The 5-yr longitudinal study tested the hypothesis that serum and urinary markers of type II collagen metabolism would be associated with radiological progression of disease in patientsExpand
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Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee.
OBJECTIVE To investigate the prognostic value of serum hyaluronic acid (HA) and keratan sulfate (KS) levels in relation to tibiofemoral osteoarthritis (OA) of the knee. METHODS Clinical andExpand
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Chondrocyte death by apoptosis is associated with cartilage matrix degradation.
OBJECTIVES To investigate the frequency of chondrocyte apoptosis in equine articular cartilage (AC) specimens and to examine the relationship between the process of cell death and the degree ofExpand
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Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3.
OBJECTIVE Chondrocyte apoptosis has been described in both human and experimentally induced osteoarthritis (OA), but its importance in the etiopathogenesis of OA is uncertain. The aims of this studyExpand
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Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage.
OBJECTIVE To investigate the relationship between biochemical markers in the synovial fluid of osteoarthritic and contralateral equine joints and gross articular cartilage pathology. DESIGNExpand
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Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee
OBJECTIVE Raised serum C reactive protein (CRP) and hyaluronate (HA) concentrations predict the progression of knee osteoarthritis (OA) in the long term but the consistency of these relations withExpand
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