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Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducibleExpand
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Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.
Huntington's disease (HD) is the result of expression of a mutated Huntingtin protein (mtHtt), and is associated with a variety of cellular dysfunctions including excessive mitochondrial fission.Expand
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Death-associated Protein Kinase Is Activated by Dephosphorylation in Response to Cerebral Ischemia*
Death-associated protein kinase (DAPK) is a calcium calmodulin-regulated serine/threonine protein kinase involved in ischemic neuronal death. In situ hybridization experiments show that DAPK mRNAExpand
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Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia
Basic helix–loop–helix PAS domain proteins form a growing family of transcription factors. These proteins are involved in the process of adaptation to cellular stresses and environmental factors suchExpand
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The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.
Stroke leads to brain damage with subsequent slow and incomplete recovery of lost brain functions. Enriched housing of stroke-injured rats provides multi-modal sensorimotor stimulation, whichExpand
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Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia
Striatal enriched protein tyrosine phosphatase (STEP) acts in the central nervous system to dephosphorylate a number of important proteins involved in synaptic function including ERK and NMDAExpand
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Activation of p53 and its target genes p21(WAF1/Cip1) and PAG608/Wig-1 in ischemic preconditioning.
A brief, 3 min period of global forebrain ischemia in the rat, induced by bilateral common carotid occlusion combined with hypotension, confers resistance to hippocampal pyramidal neurons against aExpand
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Protein Kinase C-γ and Calcium/Calmodulin-Dependent Protein Kinase II-α Are Persistently Translocated to Cell Membranes of the Rat Brain during and after Middle Cerebral Artery Occlusion
The levels of protein kinase C-γ (PKC-γ) and the calcium/calmodulin-dependent kinase II-α (CaMKII-α) were measured in crude synaptosomal (P2), particulate (P3), and cytosolic (S3) fractions of theExpand
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Preconditioning Depresses Excitatory Cell Signaling Following the Second Ischemic Insult
Ischemic tolerance was induced in the rat using the two-vessel occlusion model of cerebral ischemia. Three minutes of preconditioning ischemia with 2–3 days of interischemic interval protected theExpand
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Aberrant Cell Signaling in the Postischemic Brain: An Integrated View
This chapter examines aberrant cell signaling in the postischemic brain. During ischemia there is a disruption of the homeostatic mechanisms which initiate and terminate extracellular andExpand
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