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The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility.
Despite steadily increasing insights on the biocompatibility of PSi nanoparticles (NPs), an extensive biosafety study on the immune and red blood cells (RBCs) is still lacking. Herein, we evaluated… Expand
Improving oral absorption via drug-loaded nanocarriers: absorption mechanisms, intestinal models and rational fabrication.
Although it is acknowledged that the main impediment of orally administered therapeutic agents is their extensive and changeable pre-systemic metabolism, low absorption and instability in harsh… Expand
Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin.
- M. Lopes, N. Shrestha, +7 authors H. Santos
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 28 June 2016
The potential of nanoparticles (NPs) to overcome the barriers for oral delivery of protein drugs have led to the development of platforms capable of improving their bioavailability. However, despite… Expand
A simple and sensitive HPLC-UV method for quantitation of lovastatin in human plasma: application to a bioequivalence study.
- M. Hamidi, N. Zarei, M. Shahbazi
- Medicine, Chemistry
- Biological & pharmaceutical bulletin
- 1 September 2009
An available, simple, sensitive, and rapid method has been developed for determination of the 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor, lovastatin in human plasma. The analytical… Expand
Copolymers: efficient carriers for intelligent nanoparticulate drug targeting and gene therapy.
Copolymers are among the most promising substances used in the preparation of drug/gene delivery systems. Different categories of copolymers, including block copolymers, graft copolymers, star… Expand
Surface bioengineering of diatomite based nanovectors for efficient intracellular uptake and drug delivery.
- M. Terracciano, M. Shahbazi, +4 authors H. Santos
- Materials Science, Medicine
- 26 November 2015
Diatomite is a natural porous silica material of sedimentary origin. Due to its peculiar properties, it can be considered as a valid surrogate of synthetic porous silica for nano-based drug delivery.… Expand
Amine-modified hyaluronic acid-functionalized porous silicon nanoparticles for targeting breast cancer tumors.
- Patrick V. Almeida, M. Shahbazi, +4 authors H. Santos
- Medicine, Materials Science
- 8 August 2014
Active targeting of nanoparticles to receptor-overexpressing cancer cells has great potential for enhancing the cellular uptake of nanoparticles and for reducing fast clearance of the nanoparticles… Expand
Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers.
Porous silicon (PSi) based particulate systems are emerging as an important drug delivery system due to its advantageous properties such as biocompatibility, biodegradability and ability to tailor… Expand
Microfluidic Assembly of a Multifunctional Tailorable Composite System Designed for Site Specific Combined Oral Delivery of Peptide Drugs.
Multifunctional tailorable composite systems, specifically designed for oral dual-delivery of a peptide (glucagon-like peptide-1) and an enzymatic inhibitor (dipeptidyl peptidase 4 (DPP4)), were… Expand
Thiolation and Cell-Penetrating Peptide Surface Functionalization of Porous Silicon Nanoparticles for Oral Delivery of Insulin
During the last decades, advanced oral delivery systems to enhance the intestinal absorption of widely applicable proteins and peptides, particularly insulin, have been developed. Here,… Expand