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Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.
TLDR
Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites, and this interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis.
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Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites
TLDR
It is shown that an AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionate) receptor subunit—GluR2-interacting protein (GRIP1)—can directly interact and steer kinesin heavy chains to dendrites as a motor for AMPA receptors.
View on Nature
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
TLDR
The present work, completely supported by physical clones, provides the most comprehensive survey of a mammalian transcriptome so far, and is a valuable resource for functional genomics.
View on Nature
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
TLDR
It is shown that CMT2A patients contain a loss-of-function mutation in the motor domain of the KIF1B gene, clear indication that defects in axonal transport due to a mutated motor protein can underlie human peripheral neuropathy.
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Tubulin tyrosination navigates the kinesin-1 motor domain to axons
TLDR
It is found that the amino acid substitutions in the beta5-loop8 region transformed truncated kinesin-1 from a uni-destination (that is, the axon-specific destination) to a bi-Destination ( that is, axons and dendrites) state.
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Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1Bβ
View on Elsevier
KIF17 Dynamics and Regulation of NR2B Trafficking in Hippocampal Neurons
TLDR
Observations concerning the downregulation or upregulation of KIF17 and NR2B reveal the probable existence of a shared regulation process between the motor and its cargo and illustrate the complex mechanisms underlying the active transport and regulation ofNR2B by the molecular motor Kif17 in living hippocampal neurons.
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All kinesin superfamily protein, KIF, genes in mouse and human
TLDR
The identification and classification of all kinesin superfamily proteins (KIFs) in mouse and human genome transcripts are reported to set the foundation of KIF and intracellular transport research.
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LIS1 and NDEL1 coordinate the plus‐end‐directed transport of cytoplasmic dynein
TLDR
It is demonstrated that LIS1 suppresses the motility of cytoplasmic dynein on microtubules (MTs), whereas NDEL1 releases the blocking effect of L IS1 on cytopLasmic Dynein.
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A Novel Motor, KIF13A, Transports Mannose-6-Phosphate Receptor to Plasma Membrane through Direct Interaction with AP-1 Complex
View on Elsevier
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