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Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes.
Our failure to produce truly non-thrombogenic materials may reflect a failure to fully understand the mechanisms of biomaterial-associated thrombosis. The community has focused on minimizing… Expand
Wound care has become one of the first fields to see the benefit of a new technology: tissue engineering. Tissue engineering involves the development of new materials or devices capable of specific… Expand
Endotoxin: the uninvited guest.
In the laboratory environment where biomaterials are synthesized and their biocompatibility assessed, we find that endotoxin contamination is hard to avoid and must not be ignored. In those… Expand
The influence of biomaterials on endothelial cell thrombogenicity.
Driven by tissue engineering and regenerative medicine, endothelial cells are being used in combination with biomaterials in a number of applications for the purpose of improving blood compatibility… Expand
Vascularized organoid engineered by modular assembly enables blood perfusion.
- A. McGuigan, M. Sefton
- Materials Science, Medicine
- Proceedings of the National Academy of Sciences…
- 1 August 2006
Tissue engineering is one approach to address the donor-organ shortage, but to attain clinically significant viable cell densities in thick tissues, laboratory-constructed tissues must have an… Expand
MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling
Summary MicroRNAs are known to play regulatory roles in gene expression associated with cancer development. We analyzed levels of the microRNA miR-24 in patients with breast carcinoma and found that… Expand
Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling.
- L. Freed, F. Guilak, +7 authors G. Vunjak-Novakovic
- Engineering, Medicine
- Tissue engineering
- 18 December 2006
This article contains the collective views expressed at the second session of the workshop "Tissue Engineering--The Next Generation,'' which was devoted to the tools of tissue engineering: scaffolds,… Expand
Coagulation on biomaterials in flowing blood: some theoretical considerations.
Are truly inert biomaterials feasible? Recent mathematical models of coagulation which are reviewed here suggest that such materials are impossible. This conclusion, which is certainly consistent… Expand
Hepatic organoids for microfluidic drug screening.
- S. Au, M. D. Chamberlain, S. Mahesh, M. Sefton, A. Wheeler
- Biology, Medicine
- Lab on a chip
- 31 July 2014
We introduce the microfluidic organoids for drug screening (MODS) platform, a digital microfluidic system that is capable of generating arrays of individually addressable, free-floating,… Expand
Colorimetric assay for cellular activity in microcapsules.
Cellular activity in microcapsules was determined by a simple colorimetric assay, based on the cellular transformation of a tetrazolium salt, 3-(4,5-dimethyl-thiazol-2-yl)-2,5- diphenyl-tetrazolium… Expand