• Publications
  • Influence
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii,Expand
  • 701
  • 23
  • PDF
Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
Malaria Sporozoite Vaccine Each year, hundreds of millions of people are infected with Plasmodium falciparum, the mosquito-borne parasite that causes malaria. A preventative vaccine is greatlyExpand
  • 554
  • 23
  • PDF
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.
During 1989-1999, 11 volunteers were immunized by the bites of 1001-2927 irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain NF54 or clone 3D7/NF54. TenExpand
  • 676
  • 18
  • PDF
Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity
The efficacy of a sporozoite-based malaria vaccine is tested in humans, nonhuman primates, and mice. Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria inExpand
  • 385
  • 15
Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.
CD8+ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protectiveExpand
  • 851
  • 11
Interleukin 12 induction of interferon gamma-dependent protection against malaria.
Intraperitoneal injection of recombinant Interleukin 12 (rIL-12) at 30 ng/day for 5 days beginning 1 to 2 days before sporozoite challenge or administration of a single dose of 150 ng of rIL-122 daysExpand
  • 207
  • 10
Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria
Immunization of volunteers by the bite of mosquitoes carrying radiation-attenuated Plasmodium falciparum sporozoites protects greater than 90% of such volunteers against malaria, if adequate numbersExpand
  • 248
  • 10
  • PDF
CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.
In recent malaria sporozoite vaccine trials in humans and mice, antibodies to the sporozoite coat protein have given only modest protection against sporozoite challenge. In contrast, irradiatedExpand
  • 429
  • 9
Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.
Immunization with irradiated sporozoites protects animals and humans against malaria, and the circumsporozoite protein is a target of this protective immunity. We now report that adjuvant-freeExpand
  • 450
  • 8
  • PDF
Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine.
To enhance the efficacy of DNA malaria vaccines, we evaluated the effect on protection of immunizing with various combinations of DNA, recombinant vaccinia virus, and a synthetic peptide.Expand
  • 252
  • 8
  • PDF