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- Publications
- Influence
Coincidence of pro- and anti-inflammatory responses in the early phase of severe sepsis: Longitudinal study of mononuclear histocompatibility leukocyte antigen-DR expression, procalcitonin,…
- K. Tschaikowsky, M. Hedwig-Geissing, A. Schiele, F. Bremer, M. Schywalsky, J. Schüttler
- Medicine
- Critical care medicine
- 1 May 2002
ObjectiveTo determine the time course of histocompatibility leukocyte antigen (HLA)-DR expression in peripheral blood mononuclear cells and their relationship to markers of inflammation, organ… Expand
Propofol in rats: testing for nonlinear pharmacokinetics and modelling acute tolerance to EEG effects.
- H. Ihmsen, A. Tzabazis, M. Schywalsky, H. Schwilden
- Medicine
- European journal of anaesthesiology
- 1 March 2002
BACKGROUND AND OBJECTIVE
Pharmacokinetics of propofol in rats have usually been described using linear models. Furthermore, there are only a few investigations for a pharmacodynamic model of the… Expand
Concentration–Effect Relations, Prediction Probabilities (Pk), and Signal-to-noise Ratios of Different Electroencephalographic Parameters during Administration of Desflurane, Isoflurane, and…
- H. Ihmsen, M. Schywalsky, Regina Plettke, Michael Priller, F. Walz, H. Schwilden
- Medicine
- Anesthesiology
- 1 February 2008
Background:The authors investigated the suitability of different electroencephalographic parameters to quantify the anesthetic effect of desflurane, isoflurane, and sevoflurane in rats. Methods:Ten… Expand
EEG-controlled closed-loop dosing of propofol in rats.
- A. Tzabazis, H. Ihmsen, M. Schywalsky, H. Schwilden
- Medicine
- British journal of anaesthesia
- 1 April 2004
BACKGROUND
Based on previous pharmacokinetic and pharmacodynamic studies, we have developed an EEG-controlled closed-loop system for the i.v. hypnotic agent propofol in rats.
METHODS
Seven adult… Expand
Influence of pyrrolidine dithiocarbamate on the inflammatory response in macrophages and mouse endotoxin shock.
- M. Meisner, J. Schmidt, M. Schywalsky, K. Tschaikowsky
- Biology, Medicine
- International journal of immunopharmacology
- 2000
To analyze the immunomodulatory effect of pyrrolidine dithiocarbamate (PDTC) on the endotoxin (LPS) stimulated inflammatory response, we measured the LPS-stimulated cytokine and NO production in… Expand
Fish oil‐supplemented parenteral diets normalize splanchnic blood flow and improve killing of translocated bacteria in a low‐dose endotoxin rat model
- E. Pscheidl, M. Schywalsky, K. Tschaikowsky, T. Böke-Pröls
- Medicine, Biology
- Critical care medicine
- 1 May 2000
Objective: Intestinal ischemia decreases barrier function of the gut and enhances translocation of bacteria and toxins. Several studies indicate that fish oil can modulate prostaglandin formation and… Expand
Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats
- M. Schywalsky, H. Ihmsen, +4 authors H. Schwilden
- Medicine
- European journal of anaesthesiology
- 1 March 2003
Background and objective: We studied the pharmacokinetics and pharmacodynamics of GPI 15715 (Aquavan® injection), a new water-soluble prodrug metabolized to propofol by hydrolysis. Methods: Nine… Expand
Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats: Retraction
- M. Schywalsky, H. Ihmsen, +4 authors H. Schwilden
- Medicine
- 1 March 2003
Development of acute tolerance to the EEG effect of propofol in rats.
- H. Ihmsen, M. Schywalsky, A. Tzabazis, H. Schwilden
- Medicine
- British journal of anaesthesia
- 1 September 2005
BACKGROUND
A previous study in rats with propofol suggested the development of acute tolerance to the EEG effect. The aim of this study was to evaluate acute tolerance by means of EEG-controlled… Expand
A Polyhydroxybutyrate Biodegradable Stent: Preliminary Experience
in the Rabbit
- M. Unverdorben, A. Spielberger, +9 authors C. Vallbracht
- Medicine
- CardioVascular and Interventional Radiology
- 15 March 2002
Purpose: The lifelong persistence of
foreign bodies within the arteries may contribute to restenosis. Thus,
biodegradable devices might decrease recurrence rates.
Methods: Eleven polyhydroxybutyrate… Expand