M. Schywalsky

Publications22
h-index10
Citations519
Highly Influential Citations12
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Coincidence of pro- and anti-inflammatory responses in the early phase of severe sepsis: Longitudinal study of mononuclear histocompatibility leukocyte antigen-DR expression, procalcitonin,…
ObjectiveTo determine the time course of histocompatibility leukocyte antigen (HLA)-DR expression in peripheral blood mononuclear cells and their relationship to markers of inflammation, organ… Expand
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Propofol in rats: testing for nonlinear pharmacokinetics and modelling acute tolerance to EEG effects.
BACKGROUND AND OBJECTIVE Pharmacokinetics of propofol in rats have usually been described using linear models. Furthermore, there are only a few investigations for a pharmacodynamic model of the… Expand
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Concentration–Effect Relations, Prediction Probabilities (Pk), and Signal-to-noise Ratios of Different Electroencephalographic Parameters during Administration of Desflurane, Isoflurane, and…
Background:The authors investigated the suitability of different electroencephalographic parameters to quantify the anesthetic effect of desflurane, isoflurane, and sevoflurane in rats. Methods:Ten… Expand
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EEG-controlled closed-loop dosing of propofol in rats.
BACKGROUND Based on previous pharmacokinetic and pharmacodynamic studies, we have developed an EEG-controlled closed-loop system for the i.v. hypnotic agent propofol in rats. METHODS Seven adult… Expand
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Influence of pyrrolidine dithiocarbamate on the inflammatory response in macrophages and mouse endotoxin shock.
To analyze the immunomodulatory effect of pyrrolidine dithiocarbamate (PDTC) on the endotoxin (LPS) stimulated inflammatory response, we measured the LPS-stimulated cytokine and NO production in… Expand
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Fish oil‐supplemented parenteral diets normalize splanchnic blood flow and improve killing of translocated bacteria in a low‐dose endotoxin rat model
Objective: Intestinal ischemia decreases barrier function of the gut and enhances translocation of bacteria and toxins. Several studies indicate that fish oil can modulate prostaglandin formation and… Expand
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Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats
Background and objective: We studied the pharmacokinetics and pharmacodynamics of GPI 15715 (Aquavan® injection), a new water-soluble prodrug metabolized to propofol by hydrolysis. Methods: Nine… Expand
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Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats: Retraction
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Development of acute tolerance to the EEG effect of propofol in rats.
BACKGROUND A previous study in rats with propofol suggested the development of acute tolerance to the EEG effect. The aim of this study was to evaluate acute tolerance by means of EEG-controlled… Expand
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A Polyhydroxybutyrate Biodegradable Stent: Preliminary Experience in the Rabbit
Purpose: The lifelong persistence of foreign bodies within the arteries may contribute to restenosis. Thus, biodegradable devices might decrease recurrence rates. Methods: Eleven polyhydroxybutyrate… Expand
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