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Coincidence of pro- and anti-inflammatory responses in the early phase of severe sepsis: Longitudinal study of mononuclear histocompatibility leukocyte antigen-DR expression, procalcitonin,
TLDR
Significantly decreased monocytic HLA-DR expression was observed in both survivors and nonsurvivors at the onset of severe sepsis, and procalcitonin and C-reactive protein as well as scores on the Acute Physiology and Chronic Health Evaluation II and Sepsis Organ Failure Assessment were inversely correlated with the monocytesis.
Propofol in rats: testing for nonlinear pharmacokinetics and modelling acute tolerance to EEG effects.
TLDR
For the applied infusion scheme, prop ofol pharmacokinetics in rats were nonlinear and a development of tolerance to the electroencephalographic effect of propofol was observed during an infusion time of 90 min.
Concentration–Effect Relations, Prediction Probabilities (Pk), and Signal-to-noise Ratios of Different Electroencephalographic Parameters during Administration of Desflurane, Isoflurane, and
TLDR
If modified for spikes and burst suppression, median frequency and spectral edge frequency as well as the unmodified approximate entropy were able to assess the anesthetic effect of desflurane, isoflurane), and sevoflURane in rats.
Influence of pyrrolidine dithiocarbamate on the inflammatory response in macrophages and mouse endotoxin shock.
TLDR
PDTC is a potent immunomodulatory substance that modulates the inflammatory response in vitro and reduces mortality in mouse endotoxin shock and appears to be pluripotent, comprising both antioxidative properties and the inhibition of NF-kB.
EEG-controlled closed-loop dosing of propofol in rats.
TLDR
The feedback system presented here may be a useful tool not only for automatic drug control to maintain a defined hypnotic effect but may also be a powerful device in pharmacological studies such as the determination of dose requirements or the assessment of drug-drug interactions.
Intraorgan differences of blood flow, oxygen supply and glycogen content in the multilobular liver of normal and hemorrhagic rats.
TLDR
From the data it is concluded that in comparison to lob.
Fish oil‐supplemented parenteral diets normalize splanchnic blood flow and improve killing of translocated bacteria in a low‐dose endotoxin rat model
TLDR
In this model, diets enriched with fish oil abolish the endotoxin‐induced decrease of nutritive blood flow to the gut and ameliorate the bactericidal defense of the splanchnic region.
A Polyhydroxybutyrate Biodegradable Stent: Preliminary Experience in the Rabbit
TLDR
In the rabbit iliac artery, polyhydroxybutyrate stents caused intensive inflammatory vascular reactions which ban them from clinical use.
Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats
TLDR
Propofol from GPI 15715 showed a longer half-life, an increased volume of distribution, a delayed onset, a sustained duration of action and a greater potency with respect to concentration compared with known propofol formulations.
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