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2,3-dihydro-3-(1-pyrryl)spiro[benzofuran-2,4'-piperidine]s and 2,3-dihydro-3-(1-pyrryl)spiro[benzofuran-2,3'-pyrrolidine]s: novel antihypertensive agents.
A series of 2,3-dihydro-3-(1-pyrryl)spiro[benzofuran-2,4'-piperidine]s was synthesized and evaluated for cardiovascular activity and displayed good antihypertensive activity in the spontaneous hypertensive rat model at 50 mg/kg po. Expand
Characterization of the renal pharmacology of HP-522, a loop diuretic with uricosuric activity.
Results from this study suggest that HP-522 appears to be a loop diuretic with at least one site of action in the medullary ascending limb of Henle's loop. Expand
A sequential model of pharmacologic assays for evaluating myocardial depressant effects of potential cardiovascular drugs
A model of sequentially arranged pharmacologic assays was developed to evaluate myocardial‐depressant properties of various drugs and appeared to be adequate in that enough information can be obtained so that new pharmacologic compounds may be evaluated and decisions as to further development can be made. Expand
Effects of N6‐cyclohexyladenosine (CHA) on responses to adrenergic and cholinergic nerve stimulation in the peripheral autonomic nervous system
The adenosine derivative N6‐cyclohexyladenosine (CHA), was studied in various cardiovascular and autonomic experiments. In hemodynamic studies in dogs, CHA 0.5 mg/kg, i.v., caused moderateExpand