Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
- M. S. Chen, A. Huber, M. Schwab
- BiologyNature
- 27 January 2000
Cl cloning of nogo A, the rat complementary DNA encoding NI-220/250 is reported, showing that Nogo-A is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity.
The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
- F. Bareyre, M. Kerschensteiner, O. Raineteau, T. Mettenleiter, O. Weinmann, M. Schwab
- Biology, PsychologyNature Neuroscience
- 1 March 2004
The anatomical basis of this recovery was investigated and it was found that after incomplete spinal cord injury in rats, transected hindlimb corticospinal tract axons sprouted into the cervical gray matter to contact short and long propriospinal neurons (PSNs).
Degeneration and regeneration of axons in the lesioned spinal cord.
- M. Schwab, D. Bartholdi
- BiologyPhysiological Reviews
- 1 April 1996
This review briefly summarizes the current knowledge on the mechanisms involved in degeneration and tissue loss and in axonal regeneration subsequent to spinal cord lesions, particularly in mammals and humans.
Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions
- T. Oertle, M. E. van der Haar, M. Schwab
- BiologyJournal of Neuroscience
- 2 July 2003
Immunofluorescent staining of intracellular, endoplasmic reticulum-associated Nogo-A in cells after selective permeabilization of the plasma membrane reveals that the epitopes of Nogo -A, shown to be accessible at the cell surface, are exposed to the cytoplasm, suggesting that Nogo,A could have a second membrane topology.
In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
- M. Kerschensteiner, M. Schwab, J. Lichtman, T. Misgeld
- BiologyNature Network Boston
- 10 April 2005
Monitoring individual fluorescent axons in the spinal cords of living transgenic mice over several days after spinal injury suggests that time-lapse imaging of spinal Cord injury may provide a powerful analytical tool for assessing the pathogenesis of spinal cord injury and for evaluating therapies that enhance regeneration.
Patterns of Nogo mRNA and Protein Expression in the Developing and Adult Rat and After CNS Lesions
- A. Huber, O. Weinmann, C. Brösamle, T. Oertle, M. Schwab
- BiologyJournal of Neuroscience
- 1 May 2002
Nogo-A is a neurite growth inhibitor involved in regenerative failure and restriction of structural plasticity in the adult CNS. Three major protein products (Nogo-A, -B, and -C) are derived from…
Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
- L. Schnell, R. Schneider, R. Kolbeck, Y. Barde, M. Schwab
- BiologyNature
- 13 January 1994
In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST, and application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres.
Functions of Nogo proteins and their receptors in the nervous system
- M. Schwab
- BiologyNature Reviews Neuroscience
- 1 December 2010
The function of Nogo in the adult CNS is now understood to be that of a negative regulator of neuronal growth, leading to stabilization of the CNS wiring at the expense of extensive plastic rearrangements and regeneration after injury.
Plasticity of motor systems after incomplete spinal cord injury
- O. Raineteau, M. Schwab
- Biology, MedicineNature Reviews Neuroscience
- 1 April 2001
Functional and anatomical evidence exists that spontaneous plasticity can be potentiated by activity, as well as by specific experimental manipulations, which prepare the way to a better understanding of rehabilitation treatments and to the development of new approaches to treat spinal cord injury.
Combining Schwann Cell Bridges and Olfactory-Ensheathing Glia Grafts with Chondroitinase Promotes Locomotor Recovery after Complete Transection of the Spinal Cord
- K. Fouad, L. Schnell, M. Bunge, M. Schwab, T. Liebscher, D. Pearse
- BiologyJournal of Neuroscience
- 2 February 2005
How proven experimental treatments interact in a well-established animal model is tested, thus providing needed direction for the development of future combinatory treatment regimens.
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