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Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
Cl cloning of nogo A, the rat complementary DNA encoding NI-220/250 is reported, showing that Nogo-A is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity. Expand
The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
The anatomical basis of this recovery was investigated and it was found that after incomplete spinal cord injury in rats, transected hindlimb corticospinal tract axons sprouted into the cervical gray matter to contact short and long propriospinal neurons (PSNs). Expand
Degeneration and regeneration of axons in the lesioned spinal cord.
This review briefly summarizes the current knowledge on the mechanisms involved in degeneration and tissue loss and in axonal regeneration subsequent to spinal cord lesions, particularly in mammals and humans. Expand
Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions
Immunofluorescent staining of intracellular, endoplasmic reticulum-associated Nogo-A in cells after selective permeabilization of the plasma membrane reveals that the epitopes of Nogo -A, shown to be accessible at the cell surface, are exposed to the cytoplasm, suggesting that Nogo,A could have a second membrane topology. Expand
In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
Monitoring individual fluorescent axons in the spinal cords of living transgenic mice over several days after spinal injury suggests that time-lapse imaging of spinal Cord injury may provide a powerful analytical tool for assessing the pathogenesis of spinal cord injury and for evaluating therapies that enhance regeneration. Expand
Patterns of Nogo mRNA and Protein Expression in the Developing and Adult Rat and After CNS Lesions
Nogo-A is a neurite growth inhibitor involved in regenerative failure and restriction of structural plasticity in the adult CNS. Three major protein products (Nogo-A, -B, and -C) are derived fromExpand
Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST, and application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres. Expand
Plasticity of motor systems after incomplete spinal cord injury
Functional and anatomical evidence exists that spontaneous plasticity can be potentiated by activity, as well as by specific experimental manipulations, which prepare the way to a better understanding of rehabilitation treatments and to the development of new approaches to treat spinal cord injury. Expand
Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors
It is reported here that brain stem–spinal as well as corticospinal axons undergo regeneration and anatomical plasticity after application of IN-1 antibodies, and there is a recovery of specific reflex and locomotor functions after spinal cord injury in these adult rats. Expand
Combining Schwann Cell Bridges and Olfactory-Ensheathing Glia Grafts with Chondroitinase Promotes Locomotor Recovery after Complete Transection of the Spinal Cord
How proven experimental treatments interact in a well-established animal model is tested, thus providing needed direction for the development of future combinatory treatment regimens. Expand