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A novel and easy-to-prepare strontium(II) modified calcium phosphate bone cement with enhanced mechanical properties.
TLDR
Based on these findings, the SrCPC developed in this study could be beneficial for the treatment of defects of systemically impaired (e.g. osteoporotic) bone. Expand
Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats.
TLDR
Investigation of new bone formation in a critical-size metaphyseal defect in the femur of ovariectomized rats filled with a strontium modified calcium phosphate cement revealed an increase in bone-morphogenic protein 2, osteocalcin and osteoprotegerin expression and a statistically significant higher gene expression of alkaline phosphatase, collagen10a1 and osteocalin in the SrCPC group compared to CPC. Expand
Indirect rapid prototyping of biphasic calcium phosphate scaffolds as bone substitutes: influence of phase composition, macroporosity and pore geometry on mechanical properties
TLDR
It has been shown that wax ink-jet printing allows to process CaP-ceramic into scaffolds with highly defined geometry, exhibiting strength values that can be adjusted by phase composition and pore geometry, which is well suited to manufacture scaffolds for bone tissue engineering. Expand
Strontium modified calcium phosphate cements - approaches towards targeted stimulation of bone turnover.
TLDR
An overview of different routes that have been employed to obtain strontium-containing calcium phosphate bone cements are provided and their material characteristics as well as their biological properties based on cell culture and animal studies are described. Expand
A novel strontium(II)-modified calcium phosphate bone cement stimulates human-bone-marrow-derived mesenchymal stem cell proliferation and osteogenic differentiation in vitro.
TLDR
The in vitro effects of novel strontium-modified calcium phosphate bone cements, prepared using two different approaches on human-bone-marrow-derived mesenchymal stem cells, could be beneficial for the local treatment of defects, especially in the osteoporotic bone. Expand
Improved Sterilization of Sensitive Biomaterials with Supercritical Carbon Dioxide at Low Temperature
TLDR
It is concluded that scCO2 sterilization under addition of water, hydrogen peroxide and acetic anhydride is a very effective, gentle, non-cytotoxic and thus a promising alternative sterilization method especially for biomaterials. Expand
Relevance of osteoclast-specific enzyme activities in cell-based in vitro resorption assays.
TLDR
The activity of osteoclast-specific enzymes are analyzed as potential surrogate measures for classical pit assay, which is not applicable on irregular structured materials and a different regulation of TRAP and CTSK secretion is hypothesised for the resOrption of inorganic calcium phosphate compared to the resorption of collagenous mineralised matrix. Expand
ToF-SIMS analysis of osteoblast-like cells and their mineralized extracellular matrix on strontium enriched bone cements
TLDR
Strontium is known for its beneficial effects on osteoblasts by promoting osteoblastic cell replication and differentiation, and reducing apoptosis, the newly developed strontium enriched calcium phosphate cements are promising implant materials for osteoporotic bone. Expand
Strontium release from Sr2+-loaded bone cements and dispersion in healthy and osteoporotic rat bone.
TLDR
A two-phase model for the transport of therapeutically active Sr2-ions in bone in combination with Korsmeyer-Peppas kinetics for the Sr2+ release from bone cement is developed and successfully applied for the description of drug dispersion. Expand
Preliminary evaluation of different biomaterials for defect healing in an experimental osteoporotic rat model with dynamic PET-CT (dPET-CT) using F-18-sodium fluoride (NaF).
TLDR
PET scanning using (18)F-Sodium Fluoride to be a sensitive and useful method for evaluation of bone healing after replacement with CPC or SrCPC and reveal the most sensitive parameters for the characterisation of healing process. Expand
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