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Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex
The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two distinctExpand
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An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
Making Connections Endoplasmic reticulum (ER)–mitochondria connections have been implicated in many physiological processes, including calcium homeostasis, signaling, membrane biogenesis, andExpand
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Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum
Protein folding in the endoplasmic reticulum is a complex process whose malfunction is implicated in disease and aging. By using the cell's endogenous sensor (the unfolded protein response), weExpand
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Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile
We present a strategy for generating and analyzing comprehensive genetic-interaction maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of aggravating or alleviatingExpand
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A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria
Statement MITO-MAP, a high-density genetic interaction map in budding yeast, identifies a mitochondrial inner membrane–associated complex that promotes normal mitochondrial membrane organization andExpand
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Characterization of the expression of MHC proteins in human embryonic stem cells
Human embryonic stem (ES) cells are pluripotent cells that may be used in transplantation medicine. These cells can be induced to differentiate into cells from the three embryonic germ layers both inExpand
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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
Defining the functional relationships between proteins is critical for understanding virtually all aspects of cell biology. Large-scale identification of protein complexes has provided one importantExpand
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The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane
Summary Tail-anchored (TA) proteins, defined by the presence of a single C-terminal transmembrane domain (TMD), play critical roles throughout the secretory pathway and in mitochondria, yet theExpand
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Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells.
Human embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of in vitro fertilized human blastocysts. We examined the potential of eight growth factors [basic fibroblastExpand
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A strategy for extracting and analyzing large-scale quantitative epistatic interaction data
Recently, approaches have been developed for high-throughput identification of synthetic sick/lethal gene pairs. However, these are only a specific example of the broader phenomenon of epistasis,Expand
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