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Underediting of glutamate receptor GluR-B mRNA in malignant gliomas
- S. Maas, S. Patt, M. Schrey, A. Rich
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 20 November 2001
It is reported that in tissues from malignant human brain tumors, this editing position of glutamate receptor subunit B is substantially underedited compared with control tissues, suggesting a role for RNA editing in tumor progression and providing a molecular model explaining the occurrence of epileptic seizures in association with malignant gliomas. Expand
Expression of ether à go-go potassium channels in human gliomas
- S. Patt, Katja Preußat, +5 authors S. Heinemann
- Medicine, Biology
- Neuroscience Letters
- 30 September 2004
The findings suggest a differential expression of hEAG1 and hERG1 in gliomas depending on the malignancy grade and nature of the tumor cells, which supports the hypothesis that EAG channels are related to the oncogenic process itself. Expand
Prostaglandin E2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators.
Breast fibroblasts, particularly under the influence of inflammatory mediators, provide a potentially rich source for PGE2 production in breast tumours, whereas significant contributions from the epithelial tumour component may be restricted to cancer cells exhibiting an invasive phenotype. Expand
Human breast cancer cells contain a phosphoramidon-sensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts.
The results indicate that human breast cancer cells contain a neutral phosphoramidon-sensitive metalloproteinase which can process big ET-1 to ET- 1, and could contribute substantially to the local extracellular levels of this proposed paracrine breast fibroblast mitogen. Expand
Aromatase inhibition by 15-deoxy-prostaglandin J2 (15-dPGJ2) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production
- W. J. Andrews, Georgia Winnett, F. Rehman, P. Shanmugasundaram, Daphne van Hagen, M. Schrey
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular…
- 1 February 2005
A potential role for aromatase inhibition and the stress-response signal ceramide during the therapeutic actions of 15-dPGJ(2) and 4HPR in breast cancer treatment is highlighted, but data do not support a mediatory role for this sphingolipid during aromat enzyme inhibition by these agents. Expand
Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas
This study shows a clear differential expression of Kv1.5 in gliomas according to subtype and malignancy grade, which corresponds to previous data on the expression of voltage-gated sodium channels ingliomas, which likewise showed a low or absent expression of channel subtypes in high-grade tumors. Expand
Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity
A novel redox-sensitive elevation of ceramide levels associated with the cytotoxic response of breast cancer cells to 4HPR is described, however, a major mediatory role for this sphingolipid in this context remains equivocal. Expand
A role for phosphoinositide hydrolysis in human uterine smooth muscle during parturition.
- M. Schrey, P. Cornford, A. M. Read, P. Steer
- Biology, Medicine
- American journal of obstetrics and gynecology
- 1 October 1988
The potential for certain uterotonic agonists to use inositol lipid signaling to mobilize free arachidonic acid for prostaglandin production and to release intracellular Ca++ during excitation-contraction coupling is demonstrated. Expand
Phosphatidylinositol hydrolysis in isolated guinea-pig islets of Langerhans.
The availability of non-esterified arachidonic acid in islet cells could be regulated by changes in the activity of a phosphatidylinositol-specific phospholipase C acting in concert with a diacylglycerol lipase. Expand
Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells.
In vitro study demonstrates the potential for bombesin and glucocorticoid to regulate ET production in human breast cancer cells, which may in turn have a paracrine influence on neighboring stromal cell function. Expand