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Selective targeting of somatostatin receptor 3 to neuronal cilia
TLDR
Somatostatin receptor 3 demonstrates a unique example of a G-protein-coupled receptor not localized to "classical" pre- or postsynaptic sites, but selectively targeted to neuronal cilia.
Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies
TLDR
There appears to be a high degree of specialization among somatostatin receptor subtypes with regard to their subcellular targeting, and this subtype-selective targeting may be the underlying principal of organization that allows som atostatinergic modulation of neuronal activity via both pre- and postsynaptic mechanisms.
Immunocytochemical localization of somatostatin receptor sst2A in the rat spinal cord and dorsal root ganglia
TLDR
The present results not only provide a morphological substrate for spinal octreotide analgesia but also show that somatostatin and opioids are poised to modulate nociceptive transmission by distinct anatomical systems.
Distribution, Targeting, and Internalization of the sst4 Somatostatin Receptor in Rat Brain
TLDR
It is shown that sst4 is strictly somatodendritic and most likely functions in a postsynaptic manner and may have a previously unappreciated function during the neuronal degeneration–regeneration process.
Immunofluorescent identification of endomorphin‐2‐containing nerve fibers and terminals in the rat brain and spinal cord
TLDR
The present findings strongly suggest that endomorphin-2 may be a natural ligand for the μ-opioid receptor likely to be involved in the modulation of nociceptive transmission and reward-seeking behavior.
Differential distribution of alternatively spliced somatostatin receptor 2 isoforms (sst2A and sst2B) in rat spinal cord
TLDR
It is shown that alternative carboxy-terminal splicing is involved in cell-specific expression of somatostatin receptor sst2 isoforms in rat spinal cord, and that sst 2A and sSt2B mediate effects of som atostatin at different cellular sites.
Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co‐localization in pain‐modulatory brain regions
TLDR
The present results suggest that nociceptin and opioids are released from different terminals thereby modulating pain signals in opposite ways.
CALEB/NGC Interacts with the Golgi-associated Protein PIST*
TLDR
Co-localization studies in primary hippocampal cells and analysis of Purkinje cells of colchicine-treated rats, support the view that PIST is an interaction partner of CaleB/NGC and implicate that this interaction may play a role in the intracellular transport of CALEB/ NGC.
Immunolocalization of two mu-opioid receptor isoforms (MOR1 and MOR1B) in the rat central nervous system
TLDR
Evidence is provided that the mu receptor isoforms, MOR1 and MOR1B, exhibit a strikingly different distribution in that MOR1 appears to be the major isoform widely distributed throughout the central nervous system and MOR 1B being predominantly localized to the olfactory bulb.