• Publications
  • Influence
Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine.
Rolipram improves signal transmission in central noradrenergic neurones at a pre- and postsynaptic level, and is thus a novel approach in antidepressant therapy. In order to prove efficacy,Expand
  • 115
  • 4
Alcohol interaction of lormetazepam, mepindolol sulphate and diazepam measured by performance on the driving simulator.
Sixteen healthy volunteers of a mean age of means = 26.4 years took part in a driving simulator test in an eightfold crossover study under double-blind conditions. The additional influence of alcoholExpand
  • 19
  • 2
Rolipram versus imipramine in inpatients with major, "minor" or atypical depressive disorder: a double-blind double-dummy study aimed at testing a novel therapeutic approach.
Unlike conventional antidepressants, rolipram stimulates both the presynaptic as well as the postsynaptic component of monoaminergic transmission. Several double-blind comparative trials are on theExpand
  • 54
  • 1
Is Phosphodiesterase inhibition a new mechanism of antidepressant action?
SummaryUnlike conventional antidepressants, rolipram (a new approach in the treatment of depression) stimulates both the presynaptic and the postsynaptic component of monoaminergic transmission.Expand
  • 64
Rolipram versus nortriptyline in gerontopsychiatric inpatients with major depression
To define the therapeutic profile of the new putative antidepressant rolipram, a double-blind (double-dummy) study with 0.5 mg rolipram versus 25 mg nortriptyline three times daily was conducted inExpand
  • 3
Age-specific doses of lormetazepam as a night sedative in cases of chronic sleep disturbance.
Lormetazepam, a new benzodiazepine derivative, was tested under double blind conditions in order to find the optimal dosage for different age groups of out-patients. 120 patients suffering fromExpand
  • 7
Zur Dosiswirkungsbeziehung von Lormetazepam, Flurazepam und Flunitrazepam anhand von Ganznacht-EEG und Fragebogen
Mit der Entdeckung der elektroenzephalographischen Schlaftiefenmuster 1935 durch die Arbeitsgruppe um Loomis (6) nahm die Schlafforschung neue Dimensionen an. Erst seitdem ist es moglich,Expand