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Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine.
Rolipram improves signal transmission in central noradrenergic neurones at a pre- and postsynaptic level, and is thus a novel approach in antidepressant therapy. In order to prove efficacy,… Expand
Alcohol interaction of lormetazepam, mepindolol sulphate and diazepam measured by performance on the driving simulator.
- H. Willumeit, H. Ott, W. Neubert, K. Hemmerling, M. Schratzer, K. Fichte
- Psychology, Medicine
- 1 March 1984
Sixteen healthy volunteers of a mean age of means = 26.4 years took part in a driving simulator test in an eightfold crossover study under double-blind conditions. The additional influence of alcohol… Expand
Rolipram versus imipramine in inpatients with major, "minor" or atypical depressive disorder: a double-blind double-dummy study aimed at testing a novel therapeutic approach.
- A. Bertolino, D. Crippa, +6 authors M. Schratzer
- Psychology, Medicine
- International clinical psychopharmacology
- 1 July 1988
Unlike conventional antidepressants, rolipram stimulates both the presynaptic as well as the postsynaptic component of monoaminergic transmission. Several double-blind comparative trials are on the… Expand
Is Phosphodiesterase inhibition a new mechanism of antidepressant action?
- D. Bobon, M. Breulet, +7 authors Helmut Wachtel
- Medicine, Psychology
- European archives of psychiatry and neurological…
- 1 November 1988
SummaryUnlike conventional antidepressants, rolipram (a new approach in the treatment of depression) stimulates both the presynaptic and the postsynaptic component of monoaminergic transmission.… Expand
Rolipram versus nortriptyline in gerontopsychiatric inpatients with major depression
To define the therapeutic profile of the new putative antidepressant rolipram, a double-blind (double-dummy) study with 0.5 mg rolipram versus 25 mg nortriptyline three times daily was conducted in… Expand
Age-specific doses of lormetazepam as a night sedative in cases of chronic sleep disturbance.
Lormetazepam, a new benzodiazepine derivative, was tested under double blind conditions in order to find the optimal dosage for different age groups of out-patients. 120 patients suffering from… Expand
The normalization of sleep after surgical procedures, with and without the use of a hypnotic benzodiazepine
Zur Dosiswirkungsbeziehung von Lormetazepam, Flurazepam und Flunitrazepam anhand von Ganznacht-EEG und Fragebogen
Mit der Entdeckung der elektroenzephalographischen Schlaftiefenmuster 1935 durch die Arbeitsgruppe um Loomis (6) nahm die Schlafforschung neue Dimensionen an. Erst seitdem ist es moglich,… Expand