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AP-1 subunits: quarrel and harmony among siblings
TLDR
AP-1-mediated regulation of processes such as proliferation, differentiation, apoptosis and transformation should be considered within the context of a complex dynamic network of signalling pathways and other nuclear factors that respond simultaneously. Expand
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
TLDR
The hypothesis that proper ECM remodeling is the dominant rate-limiting process for programmed cell death, angiogenesis and osteoblast recruitment during normal skeletal morphogenesis is supported. Expand
c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin
TLDR
It is suggested that the relative activation state of these AP-1 subunits in a non-cell-autonomous, transregulatory fashion directs regeneration of the epidermis and maintenance of tissue homeostasis in skin. Expand
Function and regulation of AP-1 subunits in skin physiology and pathology
TLDR
The mouse skin has become the model of choice to study the regulation and function of AP-1 subunits in many physiological and pathological processes in vivo and in vitro, and regulates expression of important components of the cytokine network, cell surface receptors and proteases, which orchestrate the process of wound healing. Expand
JunB is essential for mammalian placentation
TLDR
Injection of junB−/− embryonic stem (ES) cells into tetraploid wild‐type blastocysts resulted in a partial rescue, in which the ES cell‐derived fetuses were no longer growth retarded and displayed a normal placental labyrinth. Expand
Th2 cell‐specific cytokine expression and allergen‐induced airway inflammation depend on JunB
TLDR
Novel functions of JunB in the development of Th2 effector cells, for a normal Th2 cytokine expression pattern and for a complete Th2‐dependent immune response in mice are demonstrated. Expand
Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone
TLDR
expression of collagenase-3 is reduced in mice lacking c-fos and is completely absent in cbfa1−/− embryos, providing the first evidence for a critical role of Cbfa 1, a major regulator of bone development, in PTH-dependent processes such as bone resorption. Expand
Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice.
TLDR
Skin homeostasis and also tissue remodelling processes like embryonic skin development and cutaneous wound healing are independent of MMP13 either owing to M MP13 dispensability or owing to functional substitution by other collagenolytic proteinases such as MMP8. Expand
Cell Cycle Promoting Activity of JunB through Cyclin A Activation*
TLDR
Cyclin A is a direct transcriptional target of JunB driving cell proliferation, which is characterized by an increase in the population of S-phase cells, while that of cells in G2/M-phase was diminished. Expand
Preeclampsia: increased expression of soluble ADAM 12
TLDR
Comparison of gene expression profiles from control and preeclamptic placental tissues taken at various age-matched gestational stages found that the soluble form of the disintegrin metalloprotease ADAM 12 represented the most upregulated transcript and could serve as an early biomarker for preeclampsia. Expand
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