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The Hair Follicle as a Dynamic Miniorgan
Hair is a primary characteristic of mammals, and exerts a wide range of functions including thermoregulation, physical protection, sensory activity, and social interactions. The hair shaft consistsExpand
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The epidermal growth factor receptor ligands at a glance
The epidermal growth factor receptor (EGFR) regulates key processes of cell biology, including proliferation, survival, and differentiation during development, tissue homeostasis, and tumorigenesis.Expand
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Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology.
The epidermal growth factor receptor (EGFR) network, including its seven ligands and four related receptors, represents one of the most complex signaling systems in biology. In many tissues,Expand
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IGF-binding protein-5: flexible player in the IGF system and effector on its own.
The multiple activities of IGF-I and -II are modulated by a family of IGF-binding proteins (IGFBP-1 to -6). Although structurally related, each IGFBP has unique properties and exerts specificExpand
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Transgenic mouse models for studying the functions of insulin‐like growth factor‐binding proteins
The insulin‐like growth factor‐binding proteins (IGFBPs) comprise a family of six related peptides that interact with high affinity with IGFs. IGFBPs compete with IGF receptors for IGF binding, andExpand
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Protein O-mannosylation is crucial for E-cadherin–mediated cell adhesion
Significance Cell–cell adhesion is essential for embryonic development, tissue morphogenesis, and tissue repair, as well as for tumor invasion and metastasis. Thus, it is of fundamental importance toExpand
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Sebocytes, multifaceted epithelial cells: lipid production and holocrine secretion.
  • M. Schneider, R. Paus
  • Biology, Medicine
  • The international journal of biochemistry & cell…
  • 1 February 2010
Sebocytes are highly specialized, sebum-producing epithelial cells that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion). These cells are mostExpand
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The EGFR network in bone biology and pathology
The resorption, formation and maintenance of bone are coordinated by the action of several hormones, growth factors and transcription factors. Recent experiments based on genetically modified mouseExpand
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A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation
Background E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrierExpand
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The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells.
Gastric cancer (GC) is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with HelicobacterExpand
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