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SUSTAINED SUPPRESSION OF TESTOSTERONE PRODUCTION BY THE LUTEINISING-HORMONE RELEASING-HORMONE AGONIST BUSERELIN IN PATIENTS WITH ADVANCED PROSTATE CARCINOMA A New Therapeutic Approach?
TLDR
Buserelin treatment may be an alternative to surgery in patients with advanced carcinoma of the prostate and regressive changes in some tumours after 3-6 months' buserel in treatment similar to those seen in surgically castrated men. Expand
Comparison of the in vitro conversion of estradiol-17β to estrone of normal and neoplastic human breast tissue
TLDR
Kinetic parameters (Km-values, coenzyme requirements and maximal velocities) of a cytoplasmic, nuclear, mitochondrial and microsomal 17 beta-HSD of normal and neoplastic human mammary tissue were compared and Sulphydryl groups were shown to be essential for catalysis. Expand
Pharmacokinetics and biotransformation of estradiol valerate in ovariectomized women.
TLDR
The pharmacokinetics and biotransformation of estradiol valerate was not different following intravenous or intramuscular injection, and daily repeated oral administration does not result in accumulation of 17 beta-estradiol and its metabolites. Expand
Sex steroid levels in serum, myometrium, and fibromyomata in correlation with cytoplasmic receptors and 17β-HSD activity in different age-groups and phases of the menstrual cycle
TLDR
The concentrations of estradiol, estrone, and progesterone in normal myometrium during the menstrual cycle were similar to those in serum except for higher levels of tissue estrone in the luteal phase. Expand
Determination of estradiol, estrone, and progesterone in serum and myometrium: correlation with the content of sex steroid receptors and 17 beta-hydroxysteroid dehydrogenase activity throughout the
TLDR
The midcycle peak of the cytoplasmic progester one-binding capacity and the increase of progesterone tissue levels at the same time were followed by an acti... Expand
Radioreceptor Assay of Human Chorionic Gonadotropin: Detection of Early Pregnancy
A rapid, sensitive, and specific radioreceptor assay for the determination of human chorionic gonadotropin and luteinizing hormone in plasma is described. Plasma membranes of bovine corpora lutea ofExpand
[First results with a new prostaglandin E2-derivate (author's transl)].
TLDR
The clinical usefulness of Pg SH B 286 has been demonstrated by the study and if the measured decline of steroid hormones--mainly progesterone--contributes to the abortifacient efficacy of this prostaglandin is yet unsolved. Expand
Treatment of prostatic cancer with LH‐RH analogues
TLDR
Twenty‐one of 32 patients with locally advanced prostatic cancer (stage C) were treated with the LH‐RH analogue Buserelin for 7‐19 months with intranasal spray application which ensured maintenance of serum testosterone within the range seen in castrated men. Expand
SUSTAINED GONADAL SUPPRESSION IN FERTILE WOMEN WITH THE LHRH AGONIST BUSERELIN
TLDR
Nine fertile women were treated with the luteinizing‐ hormone‐releasing hormone agonist buserelin and normal cyclical function occurred immediately, suggesting this reversible chemical castration may be useful for new therapeutical approaches in sexual hormone dependent diseases. Expand
Influence of the LH-RH analogue buserelin on cyclic ovarian function and on endometrium. A new approach to fertility control?
TLDR
The morphological alterations indicate that unopposed estrogen stimulation of the endometrium is the main problem of long-term contraception with the dose schedule of buserelin used. Expand
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