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Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
BACKGROUND Renal sympathetic hyperactivity is associated with hypertension and its progression, chronic kidney disease, and heart failure. We did a proof-of-principle trial of therapeutic renal… Expand
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial.
BACKGROUND Activation of renal sympathetic nerves is key to pathogenesis of essential hypertension. We aimed to assess effectiveness and safety of catheter-based renal denervation for reduction of… Expand
Renin-angiotensin system and cardiovascular risk
The renin-angiotensin system is a major regulatory system of cardiovascular and renal function. Basic research has revealed exciting new aspects, which could lead to novel or modified therapeutic… Expand
Renal sympathetic-nerve ablation for uncontrolled hypertension.
- M. Schlaich, P. Sobotka, H. Krum, E. Lambert, M. Esler
- The New England journal of medicine
- 10 December 2009
To the Editor: The renal sympathetic nerves have been identified as a major contributor to the complex pathophysiology of hypertension in both experimental models and in humans.1 Patients with… Expand
Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study
BACKGROUND Renal denervation (RDN) with radiofrequency ablation substantially reduces blood pressure in patients with treatment-resistant hypertension. We assessed the long-term antihypertensive… Expand
Renal denervation in moderate to severe CKD.
- D. Hering, F. Mahfoud, +8 authors M. Schlaich
- Journal of the American Society of Nephrology…
- 1 July 2012
Sympathetic activation contributes to the progression of CKD and is associated with adverse cardiovascular outcomes. Ablation of renal sympathetic nerves reduces sympathetic nerve activity and BP in… Expand
Sympathetic nervous activation in obesity and the metabolic syndrome--causes, consequences and therapeutic implications.
- G. Lambert, N. Straznicky, E. Lambert, J. Dixon, M. Schlaich
- Pharmacology & therapeutics
- 1 May 2010
The world wide prevalence of obesity and the metabolic syndrome is escalating. Contrary to earlier experimental evidence, human obesity is characterised by sympathetic nervous activation, with the… Expand
Effect of Renal Sympathetic Denervation on Glucose Metabolism in Patients With Resistant Hypertension: A Pilot Study
Background— Hypertension is associated with impaired glucose metabolism and insulin resistance. Chronic activation of the sympathetic nervous system may contribute to either condition. We… Expand
Sympathetic Augmentation in Hypertension: Role of Nerve Firing, Norepinephrine Reuptake, and Angiotensin Neuromodulation
Abstract—There is growing evidence that essential hypertension is commonly neurogenic and is initiated and sustained by sympathetic nervous system overactivity. Potential mechanisms include increased… Expand
Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy.
CONTEXT The biological basis for the development of major depressive disorder (MDD) remains incompletely understood. OBJECTIVE To quantify brain serotonin (5-hydroxytryptamine [5-HT]) turnover in… Expand