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Mutagenicity studies on veterinary anabolic drugs with the Salmonella/microsome test.
The restriction endonuclease Alu I induces chromosomal aberrations and mutations in the hypoxanthine phosphoribosyltransferase locus, but not in the Na+/K+ ATPase locus in V79 hamster cells.
- G. Obe, W. von der Hude, M. Scheutwinkel-Reich, A. Basler
- Biology, Medicine
- Mutation research
- 1 May 1986
The restriction endonuclease Alu I induces chromosomal aberrations and mutations in the hypoxanthine phosphoribosyltransferase (HPRT) locus as measured by 6-thioguanine resistance (TGr) in V79… Expand
Bacterial mutagenicity of the tranquilizing constituents of Valerianaceae roots.
The valepotriates developed mutagenic activity in these test systems only in the presence of S9 mix, whereas both baldrinals showedmutagenic effects in both tests with and without metabolic activation. Expand
Investigation, with the Salmonella/microsome test, of psychopharmaceuticals used in meat production.
- A. Preiss, M. Scheutwinkel-Reich, I. Fülle, H. Grohmann, H. Stan
- Mutation research
- 1 July 1982
To screen these veterinary drugs, the Salmonella/microsome test on 5 histidine-auxotrophic strains, with and without metabolic activation, foundAzaperone and xylazine were found to be weakly mutagenic. Expand
In vitro mutagenicity of valepotriates
- W. Hude, M. Scheutwinkel-Reich, R. Braun, W. Dittmar
- Chemistry, Medicine
- Archives of Toxicology
- 1 February 1985
The valepotriates were mutagenic for TA100, WP2 and WP2 uvrA− at concentrations up to about 1.0 μmole/plate when S9-mix was added to the test system and were toxic in the presence of a metabolic activation system for all strains tested. Expand
Investigation of veterinary psychopharmaceuticalwith the Salmonella/microsome test
Microbiological studies investigating mutagenicity of deep frying fat fractions and some of their components
The results show no mutagenic effects for the oxidized fractions of deep frying fats nor for the model test substances at higher concentrations, however, limited test reliability resulted from direct toxic effects on bacterial growth. Expand
Formaldehyde-induced sister chromatid exchanges in vitro and the influence of the exogenous metabolizing systems S9 mix and primary rat hepatocytes
The decrease in genotoxic effects, due to rapid metabolisation of formaldehyde in vitro and in vitro, explains the differences between results obtained in the in vitro experiments — performed without metabolizing systems — and in vivo results. Expand
Sister-chromatid exchange in Chinese hamster V79 cells exposed to quindoxin, carbadox and olaquindox.
Quindoxin, carbadox and olaquindox were subjected to the Chinese hamster V79/SCE test. All three compounds demonstrated a dose-dependent increase of SCE frequencies.
On the in-vitro mutagenicity of caramel colours
In the present study commercially available caustic and ammoniated caramel colours were tested for their mutagenic potential using the Ames assay. The test was performed using the standard test… Expand