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Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon.
BACKGROUND & AIMS Hydrogen sulfide (H(2)S) has been suggested as a novel gasomediator. We explored its unknown neuromodulatory role in human and guinea-pig colon. METHODS We used… Expand
Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome.
BACKGROUND & AIMS Pathological features in irritable bowel syndrome (IBS) include alterations in mucosal cell content and mediator release that might alter signaling to nearby submucosal neurons. … Expand
Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity.
The enteric nervous system contains excitatory and inhibitory neurons, which control contraction and relaxation of smooth muscle cells as well as gastrointestinal motor activity. Little is known… Expand
Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man
- H. Klapproth, T. Reinheimer, +7 authors I. Wessler
- Chemistry, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 21 March 1997
Abstract Acetylcholine acts as a prominent transmitter in the central and peripheral nervous system. The aim of the present study was to investigate whether mammalian non-neuronal cells can… Expand
A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen
The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve, modulates the immune system in the spleen. Vagus nerve stimulation… Expand
Sensory transmission in the gastrointestinal tract
- L. Blackshaw, S. Brookes, D. Grundy, M. Schemann
- Medicine, Biology
- Neurogastroenterology and motility : the official…
- 1 January 2007
Abstract The gastrointestinal (GI) tract must balance ostensibly opposite functions. On the one hand, it must undertake the process of digestion and absorption of nutrients. At the same time, the GI… Expand
Irritable bowel syndrome
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate… Expand
Neurochemical coding of enteric neurons in the guinea pig stomach
The aim of this study was to investigate the neurochemical coding of myenteric neurons in the guinea pig gastric corpus by using immunohistochemical methods. Antibodies and antisera against calbindin… Expand
The effects of age on the overall population and on subpopulations of myenteric neurons in the rat small intestine
Previous studies on ageing animal and human subjects have demonstrated a significant overall decline in neuronal numbers in the myenteric plexus of the enteric nervous system (ENS). Our study aimed… Expand
Changes in chemical coding of myenteric neurones in ulcerative colitis
Background: Morphological and functional changes in the enteric nervous system (ENS) have been reported in inflammatory bowel diseases but it is still uncertain whether neurochemical coding of… Expand