Enantioselective modular synthesis of 2,4-disubstituted cyclopentenones by iridium-catalyzed allylic alkylation.
- M. Schelwies, Pierre Duebon, G. Helmchen
- ChemistryAngewandte Chemie
- 3 April 2006
Carbocycles via enantioselective inter- and intramolecular iridium-catalysed allylic alkylations.
- S. Streiff, Carolin Welter, M. Schelwies, G. Lipowsky, Nicole R. Miller, G. Helmchen
- Chemistry, BiologyChemical Communications
- 8 June 2005
Carbocycles with > 90% ee were prepared via Ir-catalysed asymmetric allylic alkylation/ring closing metathesis sequences or enantioselective Ir-catalysed intramolecular allylic alkylations.
Iminosugar C-Glycoside Analogues of α-d-GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition
- Che‐hsiung Hsu, M. Schelwies, Chi‐Huey Wong
- Chemistry, BiologyJournal of Organic Chemistry
- 19 August 2014
The first synthesis of iminosugar C-glycosides of α-d-GlcNAc-1-phosphate in 10 steps starting from unprotected d-GlCNAc is described, which are lipid II mimetics endowed with potent inhibitory properties toward bacterial transglycosylases (TGase).
Glucosamine‐6‐sulfamate Analogues of Heparan Sulfate as Inhibitors of Endosulfatases
- M. Schelwies, D. Brinson, S. Hanson
- Biology, ChemistryChemBioChem
- 22 November 2010
Keeping Sulfate. The extracellular endosulfatases, which modulate signalling pathways by removing sulfate groups from heparan, can be inhibited by replacing the 6-sulfate destined for cleavage with…
Iridium-catalysed asymmetric allylic substitutions.
- G. Helmchen, Axel Dahnz, Pierre Duebon, M. Schelwies, R. Weihofen
- Chemistry, BiologyChemical Communications
- 9 February 2007
Applications, based on combinations of the allylic substitution and ring closing metathesis, indicate considerable potential of the method for the synthesis of biologically active compounds.
Alcohol amination with ammonia catalyzed by an acridine-based ruthenium pincer complex: a mechanistic study.
- X. Ye, P. Plessow, P. Hofmann
- ChemistryJournal of the American Chemical Society
- 15 April 2014
The detailed analysis of a series of possible catalytic pathways leads to the conclusion that the most favorable pathway for this catalyst does not require metal-ligand cooperation.
Selective alkylation of amines with alcohols by Cp*-iridium(III) half-sandwich complexes.
- A. Wetzel, Simone Wöckel, Michael Limbach
- ChemistryOrganic Letters
- 3 January 2013
[Cp*Ir(Pro)Cl] (Pro = prolinato) was identified among a series of Cp*-iridium half-sandwich complexes as a highly reactive and selective catalyst for the alkylation of amines with alcohols. It is…
Gold-catalyzed intermolecular addition of carbonyl compounds to 1,6-enynes.
- M. Schelwies, A. L. Dempwolff, F. Rominger, G. Helmchen
- ChemistryAngewandte Chemie
- 16 July 2007
Ru(II)-Triphos Catalyzed Amination of Alcohols with Ammonia via Ionic Species
- E. J. Derrah, M. Hanauer, P. Plessow, M. Schelwies, Marion da Silva, T. Schaub
- Chemistry
- 15 May 2015
An active and selective system for the amination of primary alcohols to primary amines with ammonia based on ruthenium and triphos as the tridentate phosphine ligand was developed. On the basis of…
Study of Precatalyst Degradation Leading to the Discovery of a New Ru0 Precatalyst for Hydrogenation and Dehydrogenation
- Aviel Anaby, M. Schelwies, Jonas Schwaben, F. Rominger, A. Hashmi, T. Schaub
- ChemistryOrganometallics
- 20 June 2018
The complex Ru-MACHO (1) is a widely used precatalyst for hydrogenation and dehydrogenation reactions under basic conditions. In an attempt to identify the active catalyst form, 1 was reacted with a…
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