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Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men.
- E. van Cauter, L. Plat, G. Copinschi
- Biology, MedicineThe Journal of clinical investigation
- 1 August 1997
The data suggest that pharmacological agents that reliably stimulate SW sleep, such as GHB, may represent a novel class of powerful GH secretagogues.
The effects of sodium oxybate on clinical symptoms and sleep patterns in patients with fibromyalgia.
Sodium oxybate effectively reduced the symptoms of pain and fatigue in patients with FM, and dramatically reduced the sleep abnormalities associated with the nonrestorative sleep characteristic of this disorder.
Subjective hypnotic efficacy of trazodone and zolpidem in DSMIII–R primary insomnia
Both trazodone and zolpidem improved self‐reported sleep latency and duration of non‐depressed, primary insomniacs; zolPidem was somewhat more efficacious at the doses studied.
Zolpidem for persistent insomnia in SSRI-treated depressed patients.
- G. Asnis, A. Chakraburtty, J. Walsh
- Medicine, PsychologyThe Journal of clinical psychiatry
- 31 October 1999
In this defined patient population, zolpidem, 10 mg, was effectively and safely co-administered with an SSRI, resulting in improved self-rated sleep, daytime functioning, and well-being.
Pharmacokinetics of gammahydroxybutyrate (GHB) in narcoleptic patients.
The data confirm that GHB treatment decreases daytime sleepiness and episodes of cataplexy, sleep paralysis, and hypnagogic hallucinations, and GHB elimination appears to be capacity-limited in some patients when administered at a fixed dose of 3 g twice nightly at a 4-hour interval.
The Pharmacokinetics of Sodium Oxybate Oral Solution following Acute and Chronic Administration to Narcoleptic Patients
- L. Borgen, R. Okerholm, A. Lai, M. Scharf
- Medicine, BiologyJournal of clinical pharmacology
- 1 March 2004
The pharmacokinetics of sodium oxybate in narcoleptic patients were not changed in any clinically significant manner when the drug was chronically administered, and theDrug was well tolerated.
Cigarette smoking associated with sleep difficulty.
It is found that sleep patterns significantly improved in a group of eight chronic smokers when they abstained from cigarette smoking, consistent with reports on the stimulant effects of nicotine.
A 2-week efficacy and safety study of eszopiclone in elderly patients with primary insomnia.
Ezopiclone was well tolerated in elderly patients with primary insomnia, and the sleep efficacy was accompanied by significantly less napping and significantly higher ratings of daytime alertness, sense of physical well-being, and several quality-of-life parameters at the higher dose.
A multicenter, placebo-controlled study evaluating zolpidem in the treatment of chronic insomnia.
- M. Scharf, T. Roth, G. Vogel, J. Walsh
- Psychology, MedicineThe Journal of clinical psychiatry
- 1 May 1994
10 mg of zolpidem was found to be safe and effective for the long-term treatment of chronic insomnia, demonstrating hypnotic efficacy without affecting sleep stages or producing tolerance effects, rebound effects, or detrimental effects on psychomotor performance.
Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia.
This study, the longest placebo-controlled, double-blind, polysomnographic trial of nightly pharmacotherapy for insomnia in the elderly, provides the best evidence to date of the sustained efficacy and safety of an insomnia medication in older adults.