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Dissociation of object and spatial visual processing pathways in human extrastriate cortex.
The existence and neuroanatomical locations of separate extrastriate visual pathways for object recognition and spatial localization were investigated in healthy young men. Regional cerebral bloodExpand
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Age-related reductions in human recognition memory due to impaired encoding.
The participation of the medial temporal cortex and other cerebral structures in the memory impairment that accompanies aging was examined by means of positron emission tomography. Cerebral bloodExpand
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Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder.
The cerebral metabolic rate for glucose was studied in 18 adults with childhood-onset obsessive-compulsive disorder (OCD) and in age- and sex-matched controls using positron emission tomography andExpand
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Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging.
BACKGROUND There are significant age and sex effects in cognitive ability and brain disease. However, sex differences in aging of human brain areas associated with nonreproductive behavior have notExpand
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Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease
Objective To determine whether the hypometabolism observed in PET images of patients with Alzheimer's disease (AD) is due entirely to brain atrophy. Background Reduced brain glucose metabolism in ADExpand
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Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis.
OBJECTIVE Clinical heterogeneity in Alzheimer's disease has been widely observed. One factor that may influence the expression of dementia in Alzheimer's disease is premorbid intellectual ability. ItExpand
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Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type.
To examine the progression of neuropsychologic and metabolic changes in the early stages of dementia of the Alzheimer type (DAT), we studied 11 midly demented patients longitudinally. Three aspectsExpand
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fMRI Shows Atypical Language Lateralization in Pediatric Epilepsy Patients
Summary:  Purpose: The goal of this study was to compare language lateralization between pediatric epilepsy patients and healthy children.
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Cholinergic stimulation alters performance and task-specific regional cerebral blood flow during working memory.
Modulation of the cholinergic neurotransmitter system results in changes in memory performance, including working memory (WM), in animals and in patients with Alzheimer disease. To identifyExpand
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High brain myo-inositol levels in the predementia phase of Alzheimer's disease in adults with Down's syndrome: a 1H MRS study.
OBJECTIVE An extra portion of chromosome 21 in Down's syndrome leads to a dementia in later life that is phenotypically similar to Alzheimer's disease. Down's syndrome therefore represents a modelExpand
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