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Cyproterone Acetate Loading to Lipid Nanoparticles for Topical Acne Treatment: Particle Characterisation and Skin Uptake
TLDR
Topical CPA treatment of skin diseases should reduce side effects currently excluding the use in males and demanding contraceptive measures in females and may be an additional therapeutic option for acne and other diseases of the pilosebaceous unit.
Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling.
TLDR
This work identified the lysophospholipid receptor S1P3 as the crucial receptor subtype for FTY720-induced myofibroblast differentiation because the effect was abolished in fibroblasts isolated from S 1P3 knockout mice.
Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype.
TLDR
Evidence is presented that S1P inhibits insulin-mediated keratinocyte growth via the activation of protein kinase C (PKC) followed by a subsequent dephosphorylation of Akt, which is of great clinical interest.
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