• Publications
  • Influence
Osteopontin: A Multifunctional Molecule Regulating Chronic Inflammation and Vascular Disease
Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory and autoimmune diseases, and it is specifically localized in and around inflammatory cells. OPN is a secretedExpand
  • 513
  • 23
The role of osteopontin in inflammatory processes
Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety ofExpand
  • 278
  • 18
Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop
The transcription factor NF-κB is an important regulator of gene expression during immune and inflammatory responses, and can also protect against apoptosis. Here we show that endothelial cellsExpand
  • 179
  • 9
Calponin and SM 22 as differentiation markers of smooth muscle: spatiotemporal distribution during avian embryonic development.
Calponin and SM 22 are two proteins related in sequence that are particularly abundant in smooth muscle cells. Here, the distribution patterns of calponin and SM 22 were compared with that of otherExpand
  • 237
  • 8
VEGF Induces Differentiation of Functional Endothelium From Human Embryonic Stem Cells: Implications for Tissue Engineering
Objective—Human embryonic stem cells (hESCs) offer a sustainable source of endothelial cells for therapeutic vascularization and tissue engineering, but current techniques for generating these cellsExpand
  • 144
  • 8
  • PDF
NF-κB Mediates αvβ3 Integrin-induced Endothelial Cell Survival
The αvβ3 integrin plays a fundamental role during the angiogenesis process by inhibiting endothelial cell apoptosis. However, the mechanism of inhibition is unknown. In this report, we show thatExpand
  • 425
  • 7
  • PDF
Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness
Abstract Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process drivenExpand
  • 145
  • 7
  • PDF
Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop.
The transcription factor NF-kappa B is an important regulator of gene expression during immune and inflammatory responses, and can also protect against apoptosis. Here we show that endothelial cellsExpand
  • 68
  • 7
The role of osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand in human microvascular endothelial cell survival.
Endothelial cell survival and antiapoptotic pathways, including those stimulated by extracellular matrix, are critical regulators of vasculogenesis, angiogenesis, endothelial repair, andExpand
  • 146
  • 6
  • PDF
Osteoprotegerin Inactivation Accelerates Advanced Atherosclerotic Lesion Progression and Calcification in Older ApoE−/− Mice
Objective—Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) superfamily of proteins, plays an important role in bone remodeling and is expressed in both mouse and humanExpand
  • 274
  • 5