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Metabolism of 2,4-dinitrotoluene and 2,6-dinitrotoluene, and their dinitrobenzyl alcohols and dinitrobenzaldehydes by Wistar and Sprague-Dawley rat liver microsomal and cytosol fractions.
It was concluded that the dinitrobenzaldehydes (2,4-DNBAl and 2,6-D NBAl) were intermediates in the oxidations of dinitRObenzyl alchols and d initrobenzoic acids of male Wistar and male Sprague-Dawley (S.D.) rat livers.
Metabolism of 2,6-dinitrotoluene in male Wistar rat.
1. Unchanged 2,6-dinitrotoluene (2,6-DNT), 2-amino-6-nitrotoluene, 2,6-dinitrobenzyl alcohol, 2-amino-6-nitrobenzyl alcohol, conjugated 2,6-dinitrobenzyl alcohol and conjugated 2-amino-6-nitrobenzyl
Enterohepatic circulation of 2,4-dinitrobenzaldehyde, a mutagenic metabolite of 2,4-dinitrotoluene, in male Wistar rat.
The results indicate that the common biliary metabolites of 2,4-DNT, 2,2-dinitrobenzyl alcohol and 2,3-d InitrobenZyl alcohol are 2, 4-dInitroben zaldehyde and its glucuronide, and suggest the enterohepatic circulation of 2-4-dinsinobenzoic acid in the metabolism of 2.4- DNT.
Metabolism of 2,4-dinitrotoluene, 2,4-dinitrobenzyl alcohol and 2,4-dinitrobenzaldehyde by rat liver microsomal and cytosol fractions.
The results indicate that 2, 4-DNAl is an intermediate in the oxidation of 2, 5-DNT and suggests that the microsomal cytochrome P-450 and alcohol dehydrogenase may play an important role in the metabolic activation of 2- 4-D NT.
Mutagenicity of some hydroxylaminotoluene derivatives towards Salmonella typhimurium in esterification systems.
Results suggested that two esterifications with glucuronic acid and sulfuric acid may play an important role in the appearance of mutagenic activity of 4AA2HAT.
Extraction of Lactic Acid Using Long Chain Amines Dissolved in Non-Polar Diluents
The present paper deals with the effect of di- and tri-n-octylamine (DOA and TOA) dissolved in non-polar diluents or the mixture of non-polar diluents and modifier on the extraction of L-lactic acid