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Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
Although hippocampal neurogenesis has been described in many adult mammals, the functional impact of this process on physiology and behavior remains unclear. In the present study, we used twoExpand
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Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain
Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains unknown when adult-born DGCs become involved in the cognitive processes. During neurogenesis, immature DGCsExpand
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Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal
BACKGROUND Depression and anxiety disorders have been linked to dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis and structural changes within the hippocampus. Unpredictable chronic mildExpand
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Paradoxical influence of hippocampal neurogenesis on working memory
To explore the function of adult hippocampal neurogenesis, we ablated cell proliferation by using two independent and complementary methods: (i) a focal hippocampal irradiation and (ii) an inducibleExpand
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Efficacy of the MCHR1 Antagonist N-[3-(1-{[4-(3,4-Difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in Mouse Models of Anxiety and Depression following
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that plays a role in the modulation of food intake and mood. In rodents, the actions of MCH are mediated via the MCHR1 receptor. TheExpand
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Substance P antagonists: meet the new drugs, same as the old drugs? Insights from transgenic animal models.
Antidepressants that primarily target the reuptake of monoamines have been highly successful treatments. However, therapies with these drugs still have several drawbacks, namely severe side effects,Expand
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Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis
Adult hippocampal neurogenesis is a remarkable form of brain plasticity through which new neurons are generated throughout life. Despite its important roles in cognition and emotion and itsExpand
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Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice
The K‐Cl cotransporter KCC2 is essential in the development of the “GABA switch” that produces a change in neuronal responses to GABA signaling from excitatory to inhibitory early in brainExpand
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Neurofunctional and neurochemical endophenotypes in mouse models of autism spectrum disorder investigated by fMRI and MRS
PURPOSE: Autism spectrum disorder (ASD) is a neuropsychiatric disorder characterised by stereotyped behaviours and impairments in communication and social interactions. Despite its neurodevelopmentalExpand